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<p>Erythropoietin-producing hepatocellular (Eph) receptors and their ligands ephrin are membrane-bound molecules that modulate diverse cellular functions in various tissues. We recently reported the co-expression of <i>Efnb1</i> (ephrin-B1) and <i>Ephb4</i> (EphB4) in steroidogenic cells of the ovary. Based on these previous findings, we examined the expression and localization of ephrin-B1 and EphB4 in steroidogenic cells of the mouse adrenal gland using RT-PCR and immunofluorescence techniques. To the best of my knowledge, ephrin-B1 and EphB4 expression patterns in the adrenal gland are virtually unknown. We found that ephrin-B1 and EphB4 were co-expressed in steroidogenic cells of zona glomerulosa (zG) and zona fasciculata (zF) in the adrenal cortex of mice. Ephrin-B1 and EphB4 were also co-expressed in cells of x-zone (xZ) in female mice. We also found that ephrin-B1 and EphB4 expression in zG was strong and weak respectively. Ephrin-B1 and EphB4 expression in cells of zF were faint in cells of both mice while strong in juxtamedullary cells of zF in male mice. Ephrin-B1 and EphB4 expression were faint and weak in xZ in female mice respectively. The study represents the first expression analysis of ephrin-B1 and EphB4 in steroidogenic cells in the adrenal glands of the male and female mice.</p>

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Ephrin-B1 and EphB4 expression and localization in steroidogenic cells of mouse adrenal gland

  • 期刊论文

  • 发表日期：

    2025年8月29日

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  • Jahagir Alam,
  • Kazushige Ogawa

摘要

Erythropoietin-producing hepatocellular (Eph) receptors and their ligands ephrin are membrane-bound molecules that modulate diverse cellular functions in various tissues. We recently reported the co-expression of Efnb1 (ephrin-B1) and Ephb4 (EphB4) in steroidogenic cells of the ovary. Based on these previous findings, we examined the expression and localization of ephrin-B1 and EphB4 in steroidogenic cells of the mouse adrenal gland using RT-PCR and immunofluorescence techniques. To the best of my knowledge, ephrin-B1 and EphB4 expression patterns in the adrenal gland are virtually unknown. We found that ephrin-B1 and EphB4 were co-expressed in steroidogenic cells of zona glomerulosa (zG) and zona fasciculata (zF) in the adrenal cortex of mice. Ephrin-B1 and EphB4 were also co-expressed in cells of x-zone (xZ) in female mice. We also found that ephrin-B1 and EphB4 expression in zG was strong and weak respectively. Ephrin-B1 and EphB4 expression in cells of zF were faint in cells of both mice while strong in juxtamedullary cells of zF in male mice. Ephrin-B1 and EphB4 expression were faint and weak in xZ in female mice respectively. The study represents the first expression analysis of ephrin-B1 and EphB4 in steroidogenic cells in the adrenal glands of the male and female mice.