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<p><i>Curculigo orchioides</i> Gaertn. (<i>Kali musli</i>) is a widely used tonic medicinal plant in Asian traditional systems, valued for restoring vitality and supporting reproductive and musculoskeletal health. In recent decades, intensive phytochemical investigations have revealed a chemically rich profile, with 173 compounds identified to date, broadly grouped into phenolics (<b>1</b>–<b>86</b>), triterpenoids and steroids (<b>87</b>–<b>126</b>), nitrogenous compounds (<b>127</b>–<b>140</b>), and other constituents (<b>141</b>–<b>173</b>). Pharmacological research reports antioxidant, anti-inflammatory, antimicrobial, antidiabetic/antihyperlipidemic, neuroprotective, and bone-protective/anti-osteoporotic activities, alongside emerging renal/uroprotective and reproductive-endocrine effects. Preclinical safety data generally indicate good short-term tolerability for root/rhizome extracts, while emphasizing preparation-dependent toxicity signals and the need for standardized, mechanism-driven and translational research. This review synthesizes traditional uses, phytochemistry, biological activities, safety considerations, and food–pharmaceutical development opportunities for <i>C. orchioides</i>.</p>

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Curculigo orchioides: a comprehensive review of traditional uses, phytonutrients, health benefits, and food-pharmaceutical applications

  • 期刊论文

  • 发表日期：

    2026年4月2日

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  • Pham Van Huyen,
  • Nguyen Thi Thu Hien,
  • Tran Thi Ngoc Hanh,
  • Tran Kim Diep,
  • Phan Nha Hoa,
  • Nguyen Huu Huong Duyen,
  • Nguyen Huu Toan Phan

摘要

Curculigo orchioides Gaertn. (Kali musli) is a widely used tonic medicinal plant in Asian traditional systems, valued for restoring vitality and supporting reproductive and musculoskeletal health. In recent decades, intensive phytochemical investigations have revealed a chemically rich profile, with 173 compounds identified to date, broadly grouped into phenolics (1–86), triterpenoids and steroids (87–126), nitrogenous compounds (127–140), and other constituents (141–173). Pharmacological research reports antioxidant, anti-inflammatory, antimicrobial, antidiabetic/antihyperlipidemic, neuroprotective, and bone-protective/anti-osteoporotic activities, alongside emerging renal/uroprotective and reproductive-endocrine effects. Preclinical safety data generally indicate good short-term tolerability for root/rhizome extracts, while emphasizing preparation-dependent toxicity signals and the need for standardized, mechanism-driven and translational research. This review synthesizes traditional uses, phytochemistry, biological activities, safety considerations, and food–pharmaceutical development opportunities for C. orchioides.