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<p><i>Paris polyphylla</i> Sm., a Himalayan ethnomedicinal plant at risk of extinction, is used in pharmaceutical production and in traditional systems such as Ayurveda and Chinese medicine to treat various illnesses. Infusions, juices, powders, and pastes are used topically or internally for jaundice, menstrual cramps, blisters, scabies, rashes, headaches, and fever. Overexploitation, habitat degradation, and unauthorized export have led to its listing as “vulnerable” by the IUCN. A systematic review following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines was conducted to assess the phytochemical profile, biological activities, cultivation practices, and commercial aspects of <i>P. polyphylla</i>. The plant is rich in bioactive constituents, particularly steroidal saponins such as diosgenin, polyphyllin D, and various Paris saponins. Pharmacological evaluations indicate that <i>P. polyphylla</i> exhibits potent anticancer, antioxidant, antibacterial, antifungal, anthelmintic, and antiviral properties. The diverse bioactivities of <i>P. polyphylla</i> highlight its potential for novel therapeutic applications, especially in cancer and infectious disease management. However, the increasing demand and declining wild populations of <i>P. polyphylla</i> necessitate urgent conservation measures. This review highlights the importance of sustainable cultivation practices, regulated harvesting, and conservation-oriented trade policies. Furthermore, the documented pharmacological properties provide a strong scientific basis for developing plant-based drug formulations and guiding future ethnopharmacological research.</p> Graphical abstract <p></p>

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Paris polyphylla Sm. A threatened herb of the Himalayas: traditional knowledge, therapeutic significance and conservation urgency

  • 期刊论文

  • 发表日期：

    2026年1月6日

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  • Tanay Barman,
  • Swaran Lata,
  • Tuyelee Das,
  • Sonkeshwar Sharma,
  • Shiv Paul,
  • Pratibha Kumari,
  • Dipika Rana

摘要

Paris polyphylla Sm., a Himalayan ethnomedicinal plant at risk of extinction, is used in pharmaceutical production and in traditional systems such as Ayurveda and Chinese medicine to treat various illnesses. Infusions, juices, powders, and pastes are used topically or internally for jaundice, menstrual cramps, blisters, scabies, rashes, headaches, and fever. Overexploitation, habitat degradation, and unauthorized export have led to its listing as “vulnerable” by the IUCN. A systematic review following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines was conducted to assess the phytochemical profile, biological activities, cultivation practices, and commercial aspects of P. polyphylla. The plant is rich in bioactive constituents, particularly steroidal saponins such as diosgenin, polyphyllin D, and various Paris saponins. Pharmacological evaluations indicate that P. polyphylla exhibits potent anticancer, antioxidant, antibacterial, antifungal, anthelmintic, and antiviral properties. The diverse bioactivities of P. polyphylla highlight its potential for novel therapeutic applications, especially in cancer and infectious disease management. However, the increasing demand and declining wild populations of P. polyphylla necessitate urgent conservation measures. This review highlights the importance of sustainable cultivation practices, regulated harvesting, and conservation-oriented trade policies. Furthermore, the documented pharmacological properties provide a strong scientific basis for developing plant-based drug formulations and guiding future ethnopharmacological research.

Graphical abstract