Scholarlink

<p>Vacuolar iron transporters (VITs) play a crucial role in iron (Fe) homeostasis by sequestering excess Fe in plant vacuoles, thereby mitigating toxicity and regulating availability. Despite their significance, the evolutionary history and structural diversity of VITs across <i>Archaeplastida</i> remain poorly understood. In this study, we identified VIT sequences from major plant lineages, including green algae, red algae, and land plants, to explore their phylogenetic relationships, distribution patterns, and structural variations. Our phylogenetic analysis reveals two distinct clades. Sequence similarity networks and structural comparisons further confirm the evolutionary divergence between these groups. Structural modeling highlights conserved features of VITs while revealing distinct adaptations in land plants, likely facilitating Fe transport regulation in terrestrial environments. The presence of both VIT and VTL in embryophytes suggests an evolutionary transition from ancestral Fe transporters in algae to more specialized forms in vascular plants. This study provides new insights into the evolution, and structural modifications in VITs, underscoring their importance in plant Fe homeostasis.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Genome-wide distribution, phylogenetic relationships, and structural insights of vacuolar iron transporters in Archaeplastida

  • 期刊论文

  • 发表日期：

    2025年6月20日

查看全文
  • Raghunandhan Namachivayam,
  • Vignesh Ponnurangan,
  • Kokiladevi Eswaran,
  • Djanaguiraman Maduraimuthu,
  • Jayakanthan Mannu,
  • Jayaprakash Paramasivam,
  • Sudhakar Duraialagaraja,
  • Neeraja Naga Chirravuri,
  • Varanavasiappan Shanmugam

摘要

Vacuolar iron transporters (VITs) play a crucial role in iron (Fe) homeostasis by sequestering excess Fe in plant vacuoles, thereby mitigating toxicity and regulating availability. Despite their significance, the evolutionary history and structural diversity of VITs across Archaeplastida remain poorly understood. In this study, we identified VIT sequences from major plant lineages, including green algae, red algae, and land plants, to explore their phylogenetic relationships, distribution patterns, and structural variations. Our phylogenetic analysis reveals two distinct clades. Sequence similarity networks and structural comparisons further confirm the evolutionary divergence between these groups. Structural modeling highlights conserved features of VITs while revealing distinct adaptations in land plants, likely facilitating Fe transport regulation in terrestrial environments. The presence of both VIT and VTL in embryophytes suggests an evolutionary transition from ancestral Fe transporters in algae to more specialized forms in vascular plants. This study provides new insights into the evolution, and structural modifications in VITs, underscoring their importance in plant Fe homeostasis.