<p>Women’s self-employment is prevalent in Nigeria. However, knowledge about its spatial variations and the underlying predictors remains largely under-explored. Drawing on the data from the Nigeria Demographic and Health Survey, 2024, we examine the spatially varying relationships between women’s self-employment and the socio-economic predictors using the geographically weighted regression (GWR). The findings reveal pronounced spatial heterogeneity. Women living in rural areas and married women are more strongly associated with self-employment in the Northeast. Conversely, women with pre-tertiary level of education and those living in poverty exert stronger influence on women’s self-employment in the Northwest and Northeast while emerging adulthood/young women significantly predicts women’s self-employment mostly in the Northwest region and some parts of the Northeast and Northcentral. Hotspot analysis further shows that women’s self-employment clusters in the Northwestern and Northeastern states, particularly in Borno, Yobe, Jigawa, Kano, Zamfara, and Katsina. These findings demonstrate that women’s self-employment is driven by place-specific constraints, underscoring the need for spatially targeted, context-sensitive policies.</p>