<p>This study investigated the multifaceted challenges faced by individuals affected by arsenicosis in Murshidabad, India, alongside how the attitudes of non-affected individuals, healthcare workers, administrative officials, and community leaders shape the experiences of the victims. Participatory Rural Appraisals (PRAs) techniques of the qualitative approach were used. Data were collected through in-depth interviews with arsenicosis patients (<i>n</i> = 36) who had been suffering for at least one year and non-patients with basic knowledge of arsenic (<i>n</i> = 23). Additionally, three Focus Group Discussions (FGDs) were conducted in three different parts of the district and included 21 participants from diverse backgrounds. The findings captured that arsenicosis victims endure substantial physical, psychological, social, and economic burdens of the disease. This suffering was exacerbated by the misconceptions among the local population and the stigma associated with the disease. Institutional failures further deepen their cycles of suffering and exclusion. Women experience additional vulnerabilities influenced by gender norms and cultural expectations. Healthcare providers struggle with limited resources and are sometimes frustrated, while religious figures play a critical role in shaping attitudes and supporting affected individuals.</p>