<p>The fire may break out anywhere in a long tunnel using point extraction ventilation; however, the role of longitudinal fire position between two dampers on smoke propagation and control is unknown. Therefore, the effect of longitudinal fire position between two dampers on smoke propagation and control was investigated, considering different heat release rates (HRRs) and damper sizes. The ceiling temperature, the velocity field on both sides of the fire, and the mass flow rate of the smoke and air were analyzed. The results demonstrated that the velocity field on both sides of the fire became asymmetric, and the flame inclination appeared when the fire deviated from the middle between the two dampers under a low exhaust rate. Interestingly, the velocity field on both sides of the fire actually became quasi-symmetric, and the flame hardly tilted when the exhaust rate rose to a certain value. This was attributed to the reallocate of the mass flow rate of smoke and fresh air based on the two-layer model. Besides, the ceiling temperature profile was not sensitive to the longitudinal fire position when the exhaust rate increased to a certain value. Finally, a formula was developed to predict the required exhaust rate for removing all smoke through two dampers, considering a fire occurring anywhere in a tunnel. These findings hope to provide helpful references for tunnel ventilation engineers.</p>