<p>Steel members in open areas like parking lots and bridges are vulnerable to localized fire. The use of fire-protection measures may slow the rate of temperature rise in such cases. However, due to uncertainty in the mechanical and thermal properties of the members and fire-protective systems, quantitative assessment of the safety of the members considering these uncertainties is necessary. The present paper describes a load and resistance factor design (LRFD)-based framework to evaluate the safety of steel and composite beams exposed to localized fire. The reliability index of the beams is calibrated with the partial safety factors of parameters such as beam strength, fuel load and thermal properties of fire-protection material and correspondingly, empirical relations are developed to define their relationship. For composite beam, it was concluded that the reliability indices were marginally sensitive to the safety factors of material strength of concrete slab and majorly depended on the safety factors of material strength of steel beam.</p>