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<p>Familial adenomatous polyposis (FAP) is a hereditary disorder caused by constitutional pathogenic variants in the <i>APC</i> gene, leading to the development of up to hundreds of colorectal adenomas and a near-inevitable risk of colorectal cancer (CRC) if untreated. Traditional management relies on prophylactic colectomy, but advances in endoscopic techniques and chemoprevention offer alternative strategies to delay or even avoid surgery. This review explores the role of endoscopic surveillance, polypectomy strategies, and chemopreventive agents in FAP management, evaluating their efficacy, limitations, and the need for personalized approaches.</p>

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Familial adenomatous polyposis: non-surgical management of large bowel disease: endoscopic and chemoprevention strategies

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月1日

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  • Maria Daca-Álvarez,
  • Andrew Latchford,
  • Maria Pellisé,
  • Francesc Balaguer

摘要

Familial adenomatous polyposis (FAP) is a hereditary disorder caused by constitutional pathogenic variants in the APC gene, leading to the development of up to hundreds of colorectal adenomas and a near-inevitable risk of colorectal cancer (CRC) if untreated. Traditional management relies on prophylactic colectomy, but advances in endoscopic techniques and chemoprevention offer alternative strategies to delay or even avoid surgery. This review explores the role of endoscopic surveillance, polypectomy strategies, and chemopreventive agents in FAP management, evaluating their efficacy, limitations, and the need for personalized approaches.