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<p>Aquatic ecosystems are seriously threatened by the uncontrolled release of untreated pharmaceutical effluent into water bodies. The current inquisition was devised to estimate the effect of untreated and vermifiltration-treated pharmaceutical effluent in fish <i>Channa punctata</i>. A substantial decline in Hb, RBC count, and PCV values and escalation in WBC count, MCH, and MCHC values were recorded in untreated effluent unveiled group in contrast to control group after 15, 30, and 45&#xa0;days of exposure. On contrasting the untreated and vermifiltration-treated groups, the treated group demonstrated significantly (<i>p</i> ≤ 0.05) higher Hb (4.12 ± 0.1 to 6.14 ± 0.07), RBC count (0.67 ± 0.11 to 1.51 ± 0.12), and PCV (9.42 ± 0.48 to 16.45 ± 0.55) following 45&#xa0;days of exposure. However, reduction in WBC count, MCH and MCHC were noticed in treated group in contrast to untreated group. Substantially enhanced alterations in serum biochemical parameters (glucose, total protein, AST, ALT, and ALP), oxidative stress marker (MDA), and antioxidant enzyme activities (SOD, CAT, and GST) were also studied in untreated effluent group. Diminution alterations in antioxidant enzyme levels of fish unveiled to treated effluent implies less toxic nature of the vermifiltration-treated effluent. Further, less ultrastructural and biomolecular anomalies were detected in treated effluent fish. The findings of the study showed that untreated pharmaceutical effluent wreaked toxicity potential on physiology of fish; however, diminution in toxicity in vermifiltration-treated group validated the efficacy of vermifiltration technology in treating pharmaceutical effluent.</p>

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Evaluation of toxicity of pharmaceutical industry effluent (untreated and vermifiltration-treated) in the blood of fresh water fish Channa punctata using different biomarkers

  • 期刊论文

  • 发表日期：

    2025年5月23日

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  • Harpal Kaur,
  • Pooja Chadha

摘要

Aquatic ecosystems are seriously threatened by the uncontrolled release of untreated pharmaceutical effluent into water bodies. The current inquisition was devised to estimate the effect of untreated and vermifiltration-treated pharmaceutical effluent in fish Channa punctata. A substantial decline in Hb, RBC count, and PCV values and escalation in WBC count, MCH, and MCHC values were recorded in untreated effluent unveiled group in contrast to control group after 15, 30, and 45 days of exposure. On contrasting the untreated and vermifiltration-treated groups, the treated group demonstrated significantly (p ≤ 0.05) higher Hb (4.12 ± 0.1 to 6.14 ± 0.07), RBC count (0.67 ± 0.11 to 1.51 ± 0.12), and PCV (9.42 ± 0.48 to 16.45 ± 0.55) following 45 days of exposure. However, reduction in WBC count, MCH and MCHC were noticed in treated group in contrast to untreated group. Substantially enhanced alterations in serum biochemical parameters (glucose, total protein, AST, ALT, and ALP), oxidative stress marker (MDA), and antioxidant enzyme activities (SOD, CAT, and GST) were also studied in untreated effluent group. Diminution alterations in antioxidant enzyme levels of fish unveiled to treated effluent implies less toxic nature of the vermifiltration-treated effluent. Further, less ultrastructural and biomolecular anomalies were detected in treated effluent fish. The findings of the study showed that untreated pharmaceutical effluent wreaked toxicity potential on physiology of fish; however, diminution in toxicity in vermifiltration-treated group validated the efficacy of vermifiltration technology in treating pharmaceutical effluent.