<p>Nano-fertilizers are one of the greatest innovations for the improvement of agriculture, promoting nutrient uptake efficiency and minimizing nutrient loss and environmental pollution index as to conventional fertilizers. The important properties of nano-fertilizers that enhance their efficiency and help minimize the phenomena involving overuse and harmful runoff are characterized as a high surface-area-to-volume ratio, high solubility, and controlled-release mechanism. Numerous nanomaterials, such as carbonaceous and metal-based ones, have been explored for their potential to modulate nutrient delivery and absorption. The coupling of nanosensors and nano-fertilizers with precision farming ensures real-time nutrient monitoring with targeted fertilization, which helps to eradicate wastage while improving crop productivity. This review addresses the synthesis, mechanisms of action, delivery pathways, and effects on soil microbiota, including comparative advantages and environmental implications. In viewing the possible advantages, key challenges hindering the mass use of nano-fertilizers include potential toxicity, production costs, farmer adoption, scalability, and regulatory compliance. Long-term effects on soil health and ecology require further study. Future research should focus on developing biodegradable, sustainable nano-fertilizers with clear regulatory frameworks.</p>