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<p>Perfluorooctanoic acid (PFOA), a persistent pollutant, poses ecological and health risks in aquatic environments. This study evaluated the effects of sub-chronic PFOA exposure at 10 and 100&#xa0;µg/L for 28 days on the growth performance, intestinal microbiota and intestinal histology in <i>Pelodiscus sinensis</i> hatchlings. High-concentration exposure (100&#xa0;µg/L) significantly reduced food intake and growth rate of turtles. The α-diversity of intestinal microbiota did not change significantly after exposure. β-diversity analysis revealed distinct separations in intestinal microbial communities, with marked alterations in relative abundances of some key taxa. Bacterial phylum Fusobacteriota, with genus <i>Cetobacterium</i>, increased significantly under PFOA stress, suggesting an adaptive enrichment. Several putatively beneficial genera, such as <i>Cupriavidus</i>, <i>Bacteroides</i>, <i>Leucobacter</i> and <i>Rothia</i>, were shown to decrease, potentially impairing host resilience. Histological analysis revealed obvious intestinal damage, including villus disruption, epithelial shedding and goblet cell rupture in the high-concentration group. Collectively, these findings indicated that sub-chronic PFOA exposure disrupted intestinal integrity and microbial balance, thereby influencing the growth of hatchling turtles. This study highlighted potential ecotoxicological threats of per- and polyfluoroalkyl substance contamination in freshwater ecosystems.</p>

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Sub-chronic exposure to perfluorooctanoic acid impairs growth, disrupts intestinal microbiota and structure in aquatic turtles

  • 期刊论文

  • 发表日期：

    2026年1月23日

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  • Shun-Hai Yu,
  • Zi-Yong Xiang,
  • Ming Mao,
  • Yi-Yun Mei,
  • Huo-Bin Tang,
  • Cang-Song Chen,
  • Hong-Liang Lu

摘要

Perfluorooctanoic acid (PFOA), a persistent pollutant, poses ecological and health risks in aquatic environments. This study evaluated the effects of sub-chronic PFOA exposure at 10 and 100 µg/L for 28 days on the growth performance, intestinal microbiota and intestinal histology in Pelodiscus sinensis hatchlings. High-concentration exposure (100 µg/L) significantly reduced food intake and growth rate of turtles. The α-diversity of intestinal microbiota did not change significantly after exposure. β-diversity analysis revealed distinct separations in intestinal microbial communities, with marked alterations in relative abundances of some key taxa. Bacterial phylum Fusobacteriota, with genus Cetobacterium, increased significantly under PFOA stress, suggesting an adaptive enrichment. Several putatively beneficial genera, such as Cupriavidus, Bacteroides, Leucobacter and Rothia, were shown to decrease, potentially impairing host resilience. Histological analysis revealed obvious intestinal damage, including villus disruption, epithelial shedding and goblet cell rupture in the high-concentration group. Collectively, these findings indicated that sub-chronic PFOA exposure disrupted intestinal integrity and microbial balance, thereby influencing the growth of hatchling turtles. This study highlighted potential ecotoxicological threats of per- and polyfluoroalkyl substance contamination in freshwater ecosystems.