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Purpose <p>To assess the long-term impact of retinopathy of prematurity (ROP) on macular function in pediatric and adult patient cohorts through the analysis of multifocal ERG (mfERG) results. Sectoral analyses were employed to uncover subtle localized findings that ring assessments could mask.</p> Methods <p>25 children and 28 adults were recruited into three groups: “ex-ROP” (individuals with a history of ROP), “preterm” (preterm-born without ROP), and “term” (term-born controls). mfERG P1 amplitudes and latencies were evaluated in five concentric rings centered on the fovea, as well as superior, inferior, nasal and temporal quadrants following Patterns 1, 2 and 3 for sectoral analysis. Macular optical coherence tomography (OCT) was performed to measure central retinal thickness and evaluate correlation with mfERG results.</p> Results <p>Using a sectoral mfERG analysis approach, applied for the first time in this population, we identified functional alterations that were not apparent with traditional global ring averages. In the pediatric cohort, sectoral evaluation revealed a significant reduction in temporal inner retinal responses in both ex-ROP and preterm children, changes that were obscured when relying solely on traditional mfERG ring analysis. Within the ex-ROP pediatric group, laser-treated eyes showed more pronounced dysfunction, with significantly prolonged P1 latencies and increased central retinal thickness compared to untreated eyes. In adults, sectoral analysis again highlighted functional abnormalities: ex-ROP and preterm participants demonstrated significantly decreased P1 amplitudes in multiple localized regions, including Rings 2 and 3. Finally, both pediatric and adult ex-ROP cohorts exhibited greater central retinal thickness than term-born controls, reinforcing the structural–functional relationship captured more sensitively through this refined sectoral method.</p> Conclusion <p>Our study demonstrated that a history of ROP is associated with diminished macular function, as evidenced by mfERG assessments, a finding more pronounced in adults compared to the younger pediatric cohort, possibly suggestive of an age-related degeneration in retinal function.</p>

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The long-term impact of retinopathy of prematurity on retinal function assessed with new patterns of mfERG analysis

  • 期刊论文

  • 发表日期：

    2026年4月29日

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  • Youjin Elizabeth Youn,
  • Allison L. Dorfman,
  • Anna Polosa,
  • Patrick Hamel,
  • Thuy Mai Luu,
  • Anne Monique Nuyt,
  • Sylvain Chemtob,
  • Shigufa Kahn Ali,
  • Cynthia X. Qian

摘要

Purpose

To assess the long-term impact of retinopathy of prematurity (ROP) on macular function in pediatric and adult patient cohorts through the analysis of multifocal ERG (mfERG) results. Sectoral analyses were employed to uncover subtle localized findings that ring assessments could mask.

Methods

25 children and 28 adults were recruited into three groups: “ex-ROP” (individuals with a history of ROP), “preterm” (preterm-born without ROP), and “term” (term-born controls). mfERG P1 amplitudes and latencies were evaluated in five concentric rings centered on the fovea, as well as superior, inferior, nasal and temporal quadrants following Patterns 1, 2 and 3 for sectoral analysis. Macular optical coherence tomography (OCT) was performed to measure central retinal thickness and evaluate correlation with mfERG results.

Results

Using a sectoral mfERG analysis approach, applied for the first time in this population, we identified functional alterations that were not apparent with traditional global ring averages. In the pediatric cohort, sectoral evaluation revealed a significant reduction in temporal inner retinal responses in both ex-ROP and preterm children, changes that were obscured when relying solely on traditional mfERG ring analysis. Within the ex-ROP pediatric group, laser-treated eyes showed more pronounced dysfunction, with significantly prolonged P1 latencies and increased central retinal thickness compared to untreated eyes. In adults, sectoral analysis again highlighted functional abnormalities: ex-ROP and preterm participants demonstrated significantly decreased P1 amplitudes in multiple localized regions, including Rings 2 and 3. Finally, both pediatric and adult ex-ROP cohorts exhibited greater central retinal thickness than term-born controls, reinforcing the structural–functional relationship captured more sensitively through this refined sectoral method.

Conclusion

Our study demonstrated that a history of ROP is associated with diminished macular function, as evidenced by mfERG assessments, a finding more pronounced in adults compared to the younger pediatric cohort, possibly suggestive of an age-related degeneration in retinal function.