Scholarlink

Background <p>We evaluated retinal function and structure in Alzheimer’s disease (AD) using photopic negative response (PhNR) from full-field electroretinography (ERG) and using&#xa0;optical coherence tomography (OCT)-based retinal layer measurements.</p> Methods <p>Ninety eyes from 61 subjects (31 controls, 30 AD patients) were included. Full-field ERGs were recorded using chromatic red-on-blue stimulation (1.7&#xa0;cd·s/m<sup>2</sup> flashes over an 8&#xa0;cd/m<sup>2</sup> blue background) in accordance with the ISCEV extended PhNR protocol. The AD group included 16 females and 14 males with moderate cognitive impairment (mean MMSE 15.5 ± 3.9). ERG a-wave, b-wave, and PhNR amplitudes were recorded. Macular and peripapillary retinal nerve fiber layer (RNFL) thicknesses were measured by OCT.</p> Results <p>A-wave (AD: − 13.4 ± 11.9&#xa0;µV, control: − 32.5 ± 13.7&#xa0;µV, <i>p</i> &lt; 0.001), b-wave (AD: 59.1 ± 28 µV, control: 156 ± 48.8 µV, <i>p</i> &lt; 0.001), PhNR (AD: − 21.4 ± 14.9&#xa0;µV, control: − 51 ± 15.4&#xa0;µV, <i>p</i> &lt; 0.001) amplitudes were lower in AD. Thicknesses of the&#xa0;central INL (AD: 25 ± 6.6&#xa0;µm, control: 25.2 ± 8.2&#xa0;µm, <i>p</i> = 0.04), inferior OPL (AD: 32.7 ± 6.2&#xa0;µm, control: 36.9 ± 8.9&#xa0;µm, <i>p</i> = 0.01), and temporal OPL (AD: 29.3 ± 5.2&#xa0;µm, control: 34.8 ± 7.0&#xa0;µm, <i>p</i> = 0.001) were reduced in AD, while other retinal layers&#xa0;showed no significant differences between groups (<i>p</i> &gt; 0.05). The b-wave amplitude showed the highest discriminative power with an AUC of 0.956, followed by the PhNR amplitude (AUC = 0.930) and the a-wave amplitude (AUC = 0.904).</p> Conclusion <p>AD was associated with a generalized reduction in full-field&#xa0;ERG amplitudes, accompanied by selective retinal layer changes on OCT. Among electrophysiological measures, b-wave amplitude demonstrated the highest ability to distinguish AD patients from controls.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Functional and structural retinal alterations in Alzheimer’s disease: insights from photopic negative response (PhNR) and OCT-based analysis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月4日

查看全文
  • Hidayet Sener,
  • Furkan Ozer,
  • Osman Ahmet Polat,
  • Beyza Ogurlu,
  • Hatice Kubra Sonmez,
  • Murat Gultekin,
  • Fatih Horozoglu

摘要

Background

We evaluated retinal function and structure in Alzheimer’s disease (AD) using photopic negative response (PhNR) from full-field electroretinography (ERG) and using optical coherence tomography (OCT)-based retinal layer measurements.

Methods

Ninety eyes from 61 subjects (31 controls, 30 AD patients) were included. Full-field ERGs were recorded using chromatic red-on-blue stimulation (1.7 cd·s/m2 flashes over an 8 cd/m2 blue background) in accordance with the ISCEV extended PhNR protocol. The AD group included 16 females and 14 males with moderate cognitive impairment (mean MMSE 15.5 ± 3.9). ERG a-wave, b-wave, and PhNR amplitudes were recorded. Macular and peripapillary retinal nerve fiber layer (RNFL) thicknesses were measured by OCT.

Results

A-wave (AD: − 13.4 ± 11.9 µV, control: − 32.5 ± 13.7 µV, p < 0.001), b-wave (AD: 59.1 ± 28 µV, control: 156 ± 48.8 µV, p < 0.001), PhNR (AD: − 21.4 ± 14.9 µV, control: − 51 ± 15.4 µV, p < 0.001) amplitudes were lower in AD. Thicknesses of the central INL (AD: 25 ± 6.6 µm, control: 25.2 ± 8.2 µm, p = 0.04), inferior OPL (AD: 32.7 ± 6.2 µm, control: 36.9 ± 8.9 µm, p = 0.01), and temporal OPL (AD: 29.3 ± 5.2 µm, control: 34.8 ± 7.0 µm, p = 0.001) were reduced in AD, while other retinal layers showed no significant differences between groups (p > 0.05). The b-wave amplitude showed the highest discriminative power with an AUC of 0.956, followed by the PhNR amplitude (AUC = 0.930) and the a-wave amplitude (AUC = 0.904).

Conclusion

AD was associated with a generalized reduction in full-field ERG amplitudes, accompanied by selective retinal layer changes on OCT. Among electrophysiological measures, b-wave amplitude demonstrated the highest ability to distinguish AD patients from controls.