Scholarlink

Background <p>High-dose opioid use (≥ 50 morphine milligram equivalents [MME]/day) is associated with increased risk of adverse outcomes, including overdose. We investigated the prevalence and risk factors for high-dose opioid use among adolescents and young adults (AYA) with inflammatory bowel disease (IBD) and other chronic digestive disorders to inform safer pain management strategies.</p> Methods <p>This retrospective cohort study identified AYA aged 15–29&#xa0;years with chronic digestive disorders who received ≥ 1 outpatient opioid prescription between March 2018 and December 2021, using Northwestern Medicine’s Electronic Data Warehouse. Short-term persistent high-dose opioid use was defined as a daily mean of ≥ 50 MME/day for ≥ 7 consecutive days. Patients were categorized into high-dose vs. non-high-dose users. We examined demographic and clinical covariates (e.g., race/ethnicity, insurance status, psychiatric diagnoses, GI and non-GI pain diagnoses, concurrent medications) using descriptive and bivariate analyses. Risk factors for high-dose use were identified via multivariate logistic regression.</p> Results <p>Among 2549 AYA patients, 12% met criteria for high-dose opioid use. Risk factors included older age within the cohort, benzodiazepine-opioid co-use, oxycodone use, and concurrent non-GI pain diagnoses (e.g., arthritis).</p> Discussion <p>Nearly 12% of AYA with chronic digestive disorders who used opioids for ≥ 7&#xa0;days received high-dose prescriptions. These findings underscore the need for safer prescribing guidelines tailored to this population. Future work should consider weight-based dosing thresholds and expanded datasets to monitor and reduce opioid-related harm in AYA with digestive disorders.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

High-Dose Opioid Use Among Adolescents and Young Adults with Chronic Digestive Disorders

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月26日

查看全文
  • Sishir Yarlagadda,
  • Lynn Huang,
  • Devyani Dharanipragada,
  • Maria Younan,
  • Ali Arshad,
  • Deysi Paniagua-Perez,
  • Megan A. Rech,
  • Mehul V. Raval,
  • Salva N. Balbale

摘要

Background

High-dose opioid use (≥ 50 morphine milligram equivalents [MME]/day) is associated with increased risk of adverse outcomes, including overdose. We investigated the prevalence and risk factors for high-dose opioid use among adolescents and young adults (AYA) with inflammatory bowel disease (IBD) and other chronic digestive disorders to inform safer pain management strategies.

Methods

This retrospective cohort study identified AYA aged 15–29 years with chronic digestive disorders who received ≥ 1 outpatient opioid prescription between March 2018 and December 2021, using Northwestern Medicine’s Electronic Data Warehouse. Short-term persistent high-dose opioid use was defined as a daily mean of ≥ 50 MME/day for ≥ 7 consecutive days. Patients were categorized into high-dose vs. non-high-dose users. We examined demographic and clinical covariates (e.g., race/ethnicity, insurance status, psychiatric diagnoses, GI and non-GI pain diagnoses, concurrent medications) using descriptive and bivariate analyses. Risk factors for high-dose use were identified via multivariate logistic regression.

Results

Among 2549 AYA patients, 12% met criteria for high-dose opioid use. Risk factors included older age within the cohort, benzodiazepine-opioid co-use, oxycodone use, and concurrent non-GI pain diagnoses (e.g., arthritis).

Discussion

Nearly 12% of AYA with chronic digestive disorders who used opioids for ≥ 7 days received high-dose prescriptions. These findings underscore the need for safer prescribing guidelines tailored to this population. Future work should consider weight-based dosing thresholds and expanded datasets to monitor and reduce opioid-related harm in AYA with digestive disorders.