Scholarlink

<p>YEATS domain-containing proteins (ENL, AF9, YEATS2, YEATS4) have emerged as key chromatin readers that recognize histone acylation marks to regulate transcription, chromatin accessibility, and DNA repair. In their recent review, Fu et al. delineate the diverse oncogenic functions of YEATS paralogs across digestive system malignancies, emphasizing their roles in integrating chromatin dynamics with signaling pathways such as PI3K/AKT, Wnt/β-catenin, HIF1α, and c-Myc. Although the structural features of YEATS domains pose challenges for pharmacological targeting, their consistent involvement in oncogenic transcriptional programs highlights them as promising epigenetic targets. This commentary critically appraises the review’s contribution, highlighting its mechanistic breadth and the implications for targeting YEATS proteins in gastrointestinal tumors.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Learning from Yeast—How YEATS Domain Proteins Read Epigenetic Marks Driving Oncogenic Programs in Gastrointestinal Tumors

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月19日

查看全文
  • Valeria Canu,
  • Giovanni Blandino

摘要

YEATS domain-containing proteins (ENL, AF9, YEATS2, YEATS4) have emerged as key chromatin readers that recognize histone acylation marks to regulate transcription, chromatin accessibility, and DNA repair. In their recent review, Fu et al. delineate the diverse oncogenic functions of YEATS paralogs across digestive system malignancies, emphasizing their roles in integrating chromatin dynamics with signaling pathways such as PI3K/AKT, Wnt/β-catenin, HIF1α, and c-Myc. Although the structural features of YEATS domains pose challenges for pharmacological targeting, their consistent involvement in oncogenic transcriptional programs highlights them as promising epigenetic targets. This commentary critically appraises the review’s contribution, highlighting its mechanistic breadth and the implications for targeting YEATS proteins in gastrointestinal tumors.