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Purpose <p>The risk of colorectal advanced adenomas (CAAs) and colorectal cancer (CRC) in siblings aged ≤ 50 of patients diagnosed with early-onset CAAs (E-CAAs), defined as having CAA at or below 50&#xa0;years, is poorly understood. This study examined the risks of adenomas, CAA, and CRC in siblings aged ≤ 50 of patients diagnosed with E-CAA.</p> Methods <p>This case-control study was conducted at a tertiary hospital in Vietnam. The participants included 96 cases who were siblings aged ≤ 50 of patients diagnosed with E-CAA. Controls were randomly selected from consecutive patients aged ≤ 50 who did not have siblings diagnosed with E-CAA. Controls were matched to cases in a 2:1 ratio for age, sex, and smoking status.</p> Results <p>The mean age was similar between cases (40.9 ± 6.0&#xa0;years) and controls (41.1 ± 6.0&#xa0;years). Except for indications for colonoscopy, there were no significant differences in the baseline demographics between the two groups. A heightened risk of CAA was documented in cases compared with controls (odds ratio [OR] 6.33; 95% confidence interval [CI] 1.43–43.8; P = 0.018). This increased risk was more pronounced in males (OR 13.7; 95% CI 1.23–262; P = 0.006). Cases had higher risks of colorectal adenomas (OR 2.43; 95% CI 1.27–4.67; P = 0.009) and colorectal neoplasia (OR 2.33; 95% CI 1.24–4.40; P = 0.011) than those in controls.</p> Conclusion <p>Siblings aged ≤ 50 of patients diagnosed with E-CAA have an increased risk of adenomas, CAA, and colorectal neoplasia. CRC screening should be initiated early in these high-risk individuals.</p>

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Risk of Advanced Adenomas in Siblings Aged ≤ 50 Years of Patients with Early-Onset Colorectal Advanced Adenomas

  • 期刊论文

  • 发表日期：

    2025年3月29日

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  • Luan Minh Dang,
  • Nhan Quang Le,
  • Huy Minh Le,
  • Diem Thi-Ngoc Vo,
  • Nguyen Lam Vuong,
  • Minh Cuong Duong,
  • Duc Trong Quach

摘要

Purpose

The risk of colorectal advanced adenomas (CAAs) and colorectal cancer (CRC) in siblings aged ≤ 50 of patients diagnosed with early-onset CAAs (E-CAAs), defined as having CAA at or below 50 years, is poorly understood. This study examined the risks of adenomas, CAA, and CRC in siblings aged ≤ 50 of patients diagnosed with E-CAA.

Methods

This case-control study was conducted at a tertiary hospital in Vietnam. The participants included 96 cases who were siblings aged ≤ 50 of patients diagnosed with E-CAA. Controls were randomly selected from consecutive patients aged ≤ 50 who did not have siblings diagnosed with E-CAA. Controls were matched to cases in a 2:1 ratio for age, sex, and smoking status.

Results

The mean age was similar between cases (40.9 ± 6.0 years) and controls (41.1 ± 6.0 years). Except for indications for colonoscopy, there were no significant differences in the baseline demographics between the two groups. A heightened risk of CAA was documented in cases compared with controls (odds ratio [OR] 6.33; 95% confidence interval [CI] 1.43–43.8; P = 0.018). This increased risk was more pronounced in males (OR 13.7; 95% CI 1.23–262; P = 0.006). Cases had higher risks of colorectal adenomas (OR 2.43; 95% CI 1.27–4.67; P = 0.009) and colorectal neoplasia (OR 2.33; 95% CI 1.24–4.40; P = 0.011) than those in controls.

Conclusion

Siblings aged ≤ 50 of patients diagnosed with E-CAA have an increased risk of adenomas, CAA, and colorectal neoplasia. CRC screening should be initiated early in these high-risk individuals.