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Objectives/Methods <p>Placebo-controlled phase II study evaluated aspirin’s effect on CDX2 mRNA and prostanoid production in native and neosquamous epithelium after successful radiofrequency ablation (RFA) in Barrett’s esophagus.</p> Results <p>At 12&#xa0;months TXB2, PGF2α, PGD2, PGE2, PGE1, and α13PGE2 increased in native squamous but not neosquamous epithelium in individuals randomized to placebo. Aspirin use significantly reduced CDX2 mRNA in native squamous epithelium, and was associated with decreases in PGE1, PGE2 and 13PGE2 in neosquamous epithelium.</p> Conclusions <p>After RFA, native squamous and neosquamous epithelium exhibit different molecular markers and responses to aspirin suggesting that different sources of squamous progenitors contribute to esophageal re-epithelization.</p>

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Effect of Aspirin on Biomarkers of Barrett’s Esophagus After Successful Eradication with Radiofrequency Ablation

  • 期刊论文

  • 发表日期：

    2025年2月11日

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  • Robert S. Bresalier,
  • Nicholas J. Shaheen,
  • Mike Hernandez,
  • Navtej Buttar,
  • Norman Marcon,
  • Sachin Wani,
  • Raman Muthusamy,
  • Gary Falk,
  • Tamara Tipps Johnson,
  • Peiying Yan,
  • Xiaofang Huo,
  • Tawana A. Castille,
  • Gary Della’Zanna,
  • Ellen Richmond,
  • J. Jack Lee,
  • Powel Brown,
  • Rhonda Souza

摘要

Objectives/Methods

Placebo-controlled phase II study evaluated aspirin’s effect on CDX2 mRNA and prostanoid production in native and neosquamous epithelium after successful radiofrequency ablation (RFA) in Barrett’s esophagus.

Results

At 12 months TXB2, PGF2α, PGD2, PGE2, PGE1, and α13PGE2 increased in native squamous but not neosquamous epithelium in individuals randomized to placebo. Aspirin use significantly reduced CDX2 mRNA in native squamous epithelium, and was associated with decreases in PGE1, PGE2 and 13PGE2 in neosquamous epithelium.

Conclusions

After RFA, native squamous and neosquamous epithelium exhibit different molecular markers and responses to aspirin suggesting that different sources of squamous progenitors contribute to esophageal re-epithelization.