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Background <p>A positive family history is considered the strongest recognizable risk factor for developing inflammatory bowel diseases (IBD) and is present in 8–12% of cases.</p> Aims <p>To determine the prevalence of familial IBD and also to compare the clinical characteristics and extraintestinal manifestations between familial and sporadic cases.</p> Methods <p>We conducted a cross-sectional study based on retrospectively-prospectively collected data from a cohort of IBD patients followed in daily clinical practice. Patients with biopsy-confirmed familial and sporadic IBD aged 16–90&#xa0;years old were included in the study. A comprehensive questionnaire was used to collect data on each site visit. Logistic regression analysis and chi-squared test were used.</p> Results <p>In total, 265 patients with IBD were included. 12.1% had a first-degree relative with IBD present (16.4% in Crohn’s disease and 5.7% in the ulcerative colitis group, <i>P</i> &lt; 0.05). Familial IBD patients were mainly females, were more frequently diagnosed with Crohn’s disease and had a higher risk for hospitalization due to an IBD flare (<i>P</i> &lt; 0.05), to undergo a surgical procedure (<i>P</i> &lt; 0.001), to require treatment with biologic agents (<i>P</i> &lt; 0.05), to develop perianal disease (<i>P</i> &lt; 0.05), and extraintestinal manifestations (<i>P</i> &lt; 0.05), mainly spine joint complications, erythema nodosum, and anterior uveitis.</p> Conclusion <p>In this study, a positive family history of IBD was present in 16.4% of Crohn’s disease and 5.7% of ulcerative colitis patients and was associated with a greater risk for hospitalization, surgical procedures, occurrence of perianal disease, need for treatment with biologic agents, and development of extraintestinal manifestations.</p>

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Prevalence, Clinical Features, and Extraintestinal Manifestations in Patients with Familial Inflammatory Bowel Diseases

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月13日

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  • Christina Liava,
  • Danai Chourmouzi,
  • Emmanouil Sinakos,
  • Theodoros Dimitroulas,
  • Christina Navrozidou,
  • Evangelos Akriviadis

摘要

Background

A positive family history is considered the strongest recognizable risk factor for developing inflammatory bowel diseases (IBD) and is present in 8–12% of cases.

Aims

To determine the prevalence of familial IBD and also to compare the clinical characteristics and extraintestinal manifestations between familial and sporadic cases.

Methods

We conducted a cross-sectional study based on retrospectively-prospectively collected data from a cohort of IBD patients followed in daily clinical practice. Patients with biopsy-confirmed familial and sporadic IBD aged 16–90 years old were included in the study. A comprehensive questionnaire was used to collect data on each site visit. Logistic regression analysis and chi-squared test were used.

Results

In total, 265 patients with IBD were included. 12.1% had a first-degree relative with IBD present (16.4% in Crohn’s disease and 5.7% in the ulcerative colitis group, P < 0.05). Familial IBD patients were mainly females, were more frequently diagnosed with Crohn’s disease and had a higher risk for hospitalization due to an IBD flare (P < 0.05), to undergo a surgical procedure (P < 0.001), to require treatment with biologic agents (P < 0.05), to develop perianal disease (P < 0.05), and extraintestinal manifestations (P < 0.05), mainly spine joint complications, erythema nodosum, and anterior uveitis.

Conclusion

In this study, a positive family history of IBD was present in 16.4% of Crohn’s disease and 5.7% of ulcerative colitis patients and was associated with a greater risk for hospitalization, surgical procedures, occurrence of perianal disease, need for treatment with biologic agents, and development of extraintestinal manifestations.