Scholarlink

<p>Photothermal therapy has emerged as a promising minimally invasive approach for biomedical applications, where nanoparticle-mediated heat generation plays a critical role. The present study aims to investigate the photothermal efficiency of green-synthesized bimetallic silver–palladium nanoparticles (AgPd NPs) and gold–palladium nanoparticles (AuPd NPs) prepared using <i>Aloe barbadensis</i> Linn. leaf gel as a natural reducing and stabilizing agent. The formation and physicochemical properties of the synthesized nanoparticles were characterized by UV–visible spectroscopy, transmission electron microscopy (TEM), and inductively coupled plasma–atomic emission spectroscopy (ICP–AES), confirming their optical properties, morphology, and elemental composition. Both AgPd NPs and AuPd NPs exhibited efficient photothermal conversion under irradiation, resulting in a significant temperature increase. Cytocompatibility was evaluated using an MTT assay on L6 rat myofibroblast cells at concentrations ranging from 20 to 100&#xa0;µg/mL for 48&#xa0;h. AgPd NPs showed concentration-dependent cytotoxicity, with pronounced toxicity at higher concentrations, whereas AuPd NPs maintained comparatively higher cell viability across the tested range. These findings indicate that <i>Aloe vera</i>-mediated AuPd NPs combine effective photothermal performance with superior biocompatibility, highlighting their potential as environmentally sustainable and safe nanomaterials for photothermal therapeutic applications.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Biocompatibility and photothermal efficiency of silver palladium (AgPd NPs) and gold palladium (AuPd NP) bimetallic nanoparticles synthesized using Aloe barbadensis Linn. leaf gel

  • 期刊论文

  • 发表日期：

    2026年3月14日

查看全文
  • Jaya R. Lakkakula,
  • Harshala S. Naik,
  • Deepika Divakaran,
  • Rohit Srivastava,
  • Rajesh Raut,
  • Imran Uddin

摘要

Photothermal therapy has emerged as a promising minimally invasive approach for biomedical applications, where nanoparticle-mediated heat generation plays a critical role. The present study aims to investigate the photothermal efficiency of green-synthesized bimetallic silver–palladium nanoparticles (AgPd NPs) and gold–palladium nanoparticles (AuPd NPs) prepared using Aloe barbadensis Linn. leaf gel as a natural reducing and stabilizing agent. The formation and physicochemical properties of the synthesized nanoparticles were characterized by UV–visible spectroscopy, transmission electron microscopy (TEM), and inductively coupled plasma–atomic emission spectroscopy (ICP–AES), confirming their optical properties, morphology, and elemental composition. Both AgPd NPs and AuPd NPs exhibited efficient photothermal conversion under irradiation, resulting in a significant temperature increase. Cytocompatibility was evaluated using an MTT assay on L6 rat myofibroblast cells at concentrations ranging from 20 to 100 µg/mL for 48 h. AgPd NPs showed concentration-dependent cytotoxicity, with pronounced toxicity at higher concentrations, whereas AuPd NPs maintained comparatively higher cell viability across the tested range. These findings indicate that Aloe vera-mediated AuPd NPs combine effective photothermal performance with superior biocompatibility, highlighting their potential as environmentally sustainable and safe nanomaterials for photothermal therapeutic applications.

Graphical Abstract