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<p>Two new furo[3,2-c]quinoline derivatives, 8-isopropyl-7-methoxy-3-methylfuro[3,2-c]quinoline (<b>1</b>) and 8-isopropyl-6-methoxy-3-methylfuro[3,2-c]quinoline (<b>2</b>), together with five known analogs (<b>3–7</b>) were isolated from the fermentation products of an endophytic fungus <i>Aspergillus versicolor</i>, which originated from cigar tobacco. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds <b>1</b> and <b>2</b> were evaluated for their antitobacco mosaic virus (anti-TMV) activity. The results revealed that compounds <b>1</b> and <b>2</b> exhibited potential anti-TMV activity, with inhibition rates of 36.5 ± 3.6 and 32.8% ± 3.4, respectively, at a concentration of 50 μg/mL. These rates are close to that of a positive control.</p>

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Two New Anti-TMV Furo[3,2-c]quinolines from the Fermentation Products of an Endophytic Aspergillus versicolor

  • 期刊论文

  • 发表日期：

    2026年6月23日

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  • Wu-Xia Xi,
  • Xin-Yao Huang,
  • Li-Ying Yang,
  • Jian-Rong Chu,
  • Long-Hui Ren,
  • Lin Yang,
  • Yu-Ping Wu,
  • Wei-Guang Wang,
  • Guang-Hui Kong,
  • Qiu-Fen Hu,
  • Gao-Kun Zhao

摘要

Two new furo[3,2-c]quinoline derivatives, 8-isopropyl-7-methoxy-3-methylfuro[3,2-c]quinoline (1) and 8-isopropyl-6-methoxy-3-methylfuro[3,2-c]quinoline (2), together with five known analogs (3–7) were isolated from the fermentation products of an endophytic fungus Aspergillus versicolor, which originated from cigar tobacco. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were evaluated for their antitobacco mosaic virus (anti-TMV) activity. The results revealed that compounds 1 and 2 exhibited potential anti-TMV activity, with inhibition rates of 36.5 ± 3.6 and 32.8% ± 3.4, respectively, at a concentration of 50 μg/mL. These rates are close to that of a positive control.