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<p>A new steroid, neofusicoccumone A (<b>1</b>), along with 11 known compounds (<b>2–12</b>), were isolated from the ethyl acetate extract of the solid fermentation of the endophytic fungus <i>Neofusicoccum</i> sp. CCT-Y4 (Botryosphaeriaceae), which was isolated from the plant <i>Hedera nepalensis</i> K. Koch (Araliaceae). Their structures were identified by NMR spectroscopy and mass spectrometry. The antimicrobial activity showed that compound <b>5</b> demonstrated significant activity on <i>Fusarium</i> oxysporum Schltdl. (Nectriaceae)(60.3%) and <i>Alternaria alternata</i> (Fr.) Keissl. (Pleosporaceae) (64.0%).</p>

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A New Steroid from Neofusicoccum sp. CCT-Y4

  • 期刊论文

  • 发表日期：

    2026年6月18日

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  • Lian-Qiong Du,
  • Xiao-Jun Li,
  • Xu-Ping Zhang,
  • Wei-Guang Wang,
  • Qian-Qian Yin,
  • Lu Gao

摘要

A new steroid, neofusicoccumone A (1), along with 11 known compounds (2–12), were isolated from the ethyl acetate extract of the solid fermentation of the endophytic fungus Neofusicoccum sp. CCT-Y4 (Botryosphaeriaceae), which was isolated from the plant Hedera nepalensis K. Koch (Araliaceae). Their structures were identified by NMR spectroscopy and mass spectrometry. The antimicrobial activity showed that compound 5 demonstrated significant activity on Fusarium oxysporum Schltdl. (Nectriaceae)(60.3%) and Alternaria alternata (Fr.) Keissl. (Pleosporaceae) (64.0%).