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<p>A new acetophenone (<b>1</b>) and 14 known compounds (<b>2–15</b>) were isolated from the roots of <i>Melicope pteleifolia</i>. Their structures were elucidated by means of comprehensive spectroscopic analysis, including 1D, 2D NMR, and HR-ESI-MS, as well as though comparison with published data. All isolated compounds were assessed for their in vitro cytotoxicity against human cancer cell lines using the SRB method. Among them, compound <b>13</b>, one of the flavonoids, exhibited the strongest cytotoxic activity, with an IC<sub>50</sub> value of 14.79 μM. Further investigation revealed that compound <b>13</b> could induce HCT116 cell apoptosis by suppressing the cleavage of Cleaved Caspase-3 and Cleaved PARP.</p>

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A New Acetophenone and Antiproliferative Constituents from the Roots of Melicope pteleifolia

  • 期刊论文

  • 发表日期：

    2026年6月25日

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  • Xin-Rui Liao,
  • Feng Wu,
  • Yan-Chao Yang,
  • Gao-Rong Zhang,
  • Wen-Zhe Ma,
  • Lai-You Wang,
  • Wen-Jian Lan

摘要

A new acetophenone (1) and 14 known compounds (2–15) were isolated from the roots of Melicope pteleifolia. Their structures were elucidated by means of comprehensive spectroscopic analysis, including 1D, 2D NMR, and HR-ESI-MS, as well as though comparison with published data. All isolated compounds were assessed for their in vitro cytotoxicity against human cancer cell lines using the SRB method. Among them, compound 13, one of the flavonoids, exhibited the strongest cytotoxic activity, with an IC50 value of 14.79 μM. Further investigation revealed that compound 13 could induce HCT116 cell apoptosis by suppressing the cleavage of Cleaved Caspase-3 and Cleaved PARP.