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<p>A new chalconoid derivative, (<i>E</i>)-1-(2,6-dihydroxy-4-methoxyphenyl)-3-(4-hydroxy-3,5- imethoxyphenyl)prop-2-en-1-one (<b>1</b>), has been isolated from the roots of <i>Litsea perrottetii</i>, together with seven known compounds, 2′,4′,6′-trihydroxychalcone (<b>2</b>), flavokawain B (<b>3</b>), myricetin (<b>4</b>), luteolin (<b>5</b>), (+)-catechin (<b>6</b>), (–)-epicatechin (<b>7</b>), and N-trans-feruloyl-3-O-methyldopamine (<b>8</b>). The structure of the new compound <b>1</b> was determined through spectroscopic and MS analyses. Among the isolated compounds, compounds <b>1</b>, <b>3</b>, and <b>5</b> showed potent inhibition, with IC<sub>50</sub> values of 17.58 ± 2.02, 15.24 ± 1.13, and 10.04 ± 0.84 μM, respectively, against LPS-induced NO generation.</p>

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A New Chalconoid Derivative and Anti-Inflammatory Constituents from Litsea perrottetii

  • 期刊论文

  • 发表日期：

    2026年6月19日

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  • Ching-Ju Hung,
  • Zih-Rong Chen,
  • Chien-Liang Lin,
  • Tsung-Hsien Chang,
  • Chia-Ching Liaw,
  • Ming-Jen Cheng,
  • Jih-Jung Chen

摘要

A new chalconoid derivative, (E)-1-(2,6-dihydroxy-4-methoxyphenyl)-3-(4-hydroxy-3,5- imethoxyphenyl)prop-2-en-1-one (1), has been isolated from the roots of Litsea perrottetii, together with seven known compounds, 2′,4′,6′-trihydroxychalcone (2), flavokawain B (3), myricetin (4), luteolin (5), (+)-catechin (6), (–)-epicatechin (7), and N-trans-feruloyl-3-O-methyldopamine (8). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolated compounds, compounds 1, 3, and 5 showed potent inhibition, with IC50 values of 17.58 ± 2.02, 15.24 ± 1.13, and 10.04 ± 0.84 μM, respectively, against LPS-induced NO generation.