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<p>Two new chromones, 8-(hydroxymethyl)-6-isopropyl-2-methyl-4<i>H</i>-chromen-4-one (<b>1</b>) and 8-(hydroxymethyl)-6-isopropyl-5-methoxy-2-methyl-4<i>H</i>-chromen-4-one (<b>2</b>), along with five known ones (<b>3–7</b>) were isolated from the fungus <i>Aspergillus versicolor</i>, which derived from cigar tobacco. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds <b>1</b> and <b>2</b> were evaluated for antibacterial activity against <i>Pseudomonas syringae</i> (the main pathogenic sources of tobacco angular spot disease). The results revealed that compounds <b>1</b> and <b>2</b> exhibited inhibitory activity with MIC<sub>50</sub> values of 5.2 and 4.6 μg/mL, respectively. These rates are lower than that of the positive control (agricultural streptomycin, with MIC<sub>50</sub> of 2.2 μg/mL).</p>

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Two New Chromone Derivatives from the Fungus Aspergillus versicolor Isolated from Cigar Tobacco

  • 期刊论文

  • 发表日期：

    2026年6月17日

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  • Dan He,
  • Si-Si Lin,
  • Jian-Yong Cheng,
  • Cheng Zhang,
  • Yuan-Xian Zheng,
  • Yong-Jun Zhang,
  • Tao Wen,
  • Jian-Duo Zhang,
  • Qiu-Fen Hu,
  • Jin Li,
  • Hou-Fa Zhou

摘要

Two new chromones, 8-(hydroxymethyl)-6-isopropyl-2-methyl-4H-chromen-4-one (1) and 8-(hydroxymethyl)-6-isopropyl-5-methoxy-2-methyl-4H-chromen-4-one (2), along with five known ones (3–7) were isolated from the fungus Aspergillus versicolor, which derived from cigar tobacco. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were evaluated for antibacterial activity against Pseudomonas syringae (the main pathogenic sources of tobacco angular spot disease). The results revealed that compounds 1 and 2 exhibited inhibitory activity with MIC50 values of 5.2 and 4.6 μg/mL, respectively. These rates are lower than that of the positive control (agricultural streptomycin, with MIC50 of 2.2 μg/mL).