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<p>In our continuous effort to investigate hypoglycemic constituents from <i>Viburnum</i> plants, phytochemical research has discovered one undescribed tetrahydrofuran lignan, viburceol A (<b>1</b>), together with five known lignan constituents (<b>2–6</b>) from the leaves of <i>Viburnum cylindricum</i>. The structure of compound <b>1</b> was determined by spectroscopic analysis, including 1D and 2D NMR, and HR-ESI-MS, as well as DP4+ NMR and ECD calculations. Additionally, the α-glucosidase inhibitory activity of all the isolates was evaluated, among which compounds <b>5</b> and <b>6</b> exhibited moderate α-glucosidase inhibitory activity.</p>

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Lignan Constituents from the Leaves of Viburnum cylindricum and Their Potential α-glucosidase Inhibitory Activity

  • 期刊论文

  • 发表日期：

    2026年6月17日

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  • Yu-Fei Yang,
  • Meng-Ya Yang,
  • Ya-Jiao Chen,
  • Jian-Hua Shao,
  • Chun-Chao Zhao

摘要

In our continuous effort to investigate hypoglycemic constituents from Viburnum plants, phytochemical research has discovered one undescribed tetrahydrofuran lignan, viburceol A (1), together with five known lignan constituents (2–6) from the leaves of Viburnum cylindricum. The structure of compound 1 was determined by spectroscopic analysis, including 1D and 2D NMR, and HR-ESI-MS, as well as DP4+ NMR and ECD calculations. Additionally, the α-glucosidase inhibitory activity of all the isolates was evaluated, among which compounds 5 and 6 exhibited moderate α-glucosidase inhibitory activity.