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<p>Seven aglycones and one progenin (xyloside) were obtained as a result of soft-acid hydrolysis of the glycosidic fraction corresponding cucumariosides A<sub>4</sub> group isolated from the sea cucumber <i>Cucumaria japonica</i>. Their structures were elucidated by 1D and 2D NMR and HR-ESI-MS. The availability of the isolated derivatives to interact with recombinant cytochromes P450 of <i>Mycobacterium tuberculosis</i> (CYP51, CYP124, CYP125, CYP142), <i>Candida albicans</i> (CYP51), <i>C. glabrata</i> (CYP51), <i>C. krusei</i> (CYP51), and <i>Homo sapiens</i> (CYP51) was studied. Pronounced interaction was found for progenin <b>10</b> with CYP124 of <i>M. tuberculosis</i> and CYP51 of <i>C. glabrata</i>; however, it also interacted with CYP51 of <i>Homo sapiens</i>.</p>

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The Obtaining and Structure Elucidation of the Artifact Aglycones of Triterpene Glycosides from the Sea Cucumber Cucumaria japonica and Their Interactions with Cytochromes P450 of Mycobacterium tuberculosis and Three Species of the Genus Candida

  • 期刊论文

  • 发表日期：

    2026年3月1日

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  • A. S. Silchenko,
  • K. M. Tabakmakher,
  • L. A. Kaluzhskiy,
  • A. S. Ivanov,
  • T. V. Tsybruk,
  • A. Yu. Karputs,
  • T. S. Varaksa,
  • A. A. Gilep,
  • N. V. Strushkevich,
  • A. I. Kalinovsky,
  • S. A. Avilov,
  • R. S. Popov,
  • N. V. Ivanchina,
  • P. S. Dmitrenok,
  • V. I. Kalinin

摘要

Seven aglycones and one progenin (xyloside) were obtained as a result of soft-acid hydrolysis of the glycosidic fraction corresponding cucumariosides A4 group isolated from the sea cucumber Cucumaria japonica. Their structures were elucidated by 1D and 2D NMR and HR-ESI-MS. The availability of the isolated derivatives to interact with recombinant cytochromes P450 of Mycobacterium tuberculosis (CYP51, CYP124, CYP125, CYP142), Candida albicans (CYP51), C. glabrata (CYP51), C. krusei (CYP51), and Homo sapiens (CYP51) was studied. Pronounced interaction was found for progenin 10 with CYP124 of M. tuberculosis and CYP51 of C. glabrata; however, it also interacted with CYP51 of Homo sapiens.