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<p>Three new terpenoids <b>1</b>–<b>3</b> (two tigliane-type diterpenoids and one daucane sesquiterpenoid), along with six known terpenoids <b>4–9</b>, were isolated from the aerial parts of <i>Daphne pedunculata</i> H. F. Zhou ex C. Y. Chang. The structures of three new terpenoids were elucidated through a combination of HR-ESI-MS, NMR spectroscopic techniques and the quantum ECD analysis. The <i>in vitro</i> cytotoxicity experiments indicated that compounds 6<i>α</i>,7<i>α</i>-epoxy-4<i>β</i>,5<i>β</i>,9<i>α</i>,13<i>α</i>,20-pentahydroxytigli-1-en-3-one 13-<i>O</i>-octanoate (<b>2</b>), 6<i>α</i>,7<i>α</i>-epoxy-5<i>β</i>-hydroxy-12-deoxyphorbol-13-decanoate (<b>5</b>), (23<i>E</i>)-cycloart-23-ene-3<i>α</i>,25-diol (<b>8</b>) exhibited moderate cytotoxic activities against A549, MDA-MB-231, and SW480 cell lines. Furthermore, compound <b>2</b> inhibited the growth of A549 cells in a concentration-dependent manner.</p>

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Terpenoids from Daphne pedunculata and Their Cytotoxic Activities In Vitro

  • 期刊论文

  • 发表日期：

    2026年3月1日

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  • Lin Li,
  • Fu-Qiang Song,
  • Ping-Jing Yu,
  • Xing-Li Zhu,
  • Xian Li

摘要

Three new terpenoids 1–3 (two tigliane-type diterpenoids and one daucane sesquiterpenoid), along with six known terpenoids 4–9, were isolated from the aerial parts of Daphne pedunculata H. F. Zhou ex C. Y. Chang. The structures of three new terpenoids were elucidated through a combination of HR-ESI-MS, NMR spectroscopic techniques and the quantum ECD analysis. The in vitro cytotoxicity experiments indicated that compounds 6α,7α-epoxy-4β,5β,9α,13α,20-pentahydroxytigli-1-en-3-one 13-O-octanoate (2), 6α,7α-epoxy-5β-hydroxy-12-deoxyphorbol-13-decanoate (5), (23E)-cycloart-23-ene-3α,25-diol (8) exhibited moderate cytotoxic activities against A549, MDA-MB-231, and SW480 cell lines. Furthermore, compound 2 inhibited the growth of A549 cells in a concentration-dependent manner.