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<p>A novel chalcone glycoside, named 4-hydroxy-6′′-(10′′,12′′-dimethoxy-11′′-hydroxybenzoyl)-6-<i>O</i>-<i>β</i>-D-glucopyranosyl-4′-rutinosylchalcone (<b>1</b>), together with six known chalcone glycosides (<b>2</b>–<b>7</b>) were obtained from <i>Citrus medica</i> L. var. <i>sarcodactylis</i> Swingle for the first time. Their structures were determined by analyzing spectral data and comparing with references. Among them, compounds <b>1</b>, <b>3</b>, and <b>5</b> exhibited important hepatoprotective activities at the concentration of 10 μM, with survival rates of 77.51 ± 1.05%, 71.62 ± 1.58%, and 67.94 ± 1.59%, respectively.</p>

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Isolation and Characterization of Chalcone Glycosides with Hepatoprotective Activities from the Fruits of Citrus medica var. sarcodactylis

  • 期刊论文

  • 发表日期：

    2026年3月1日

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  • Wen-Min Liu,
  • Rong-Rui Wei,
  • Qin-Ge Ma

摘要

A novel chalcone glycoside, named 4-hydroxy-6′′-(10′′,12′′-dimethoxy-11′′-hydroxybenzoyl)-6-O-β-D-glucopyranosyl-4′-rutinosylchalcone (1), together with six known chalcone glycosides (2–7) were obtained from Citrus medica L. var. sarcodactylis Swingle for the first time. Their structures were determined by analyzing spectral data and comparing with references. Among them, compounds 1, 3, and 5 exhibited important hepatoprotective activities at the concentration of 10 μM, with survival rates of 77.51 ± 1.05%, 71.62 ± 1.58%, and 67.94 ± 1.59%, respectively.