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<p>To explore more antibacterial natural products, an extract from fermentation products of tobacco endophytic <i>Aspergillus</i> sp. (YATS-225) was investigated. As a result, five pyrroloquinolines (<b>1–5</b>) were isolated. Among them, two newly discovered pyrrolo[1,2-<i>a</i>]quinolin (<b>1</b> and <b>2</b>) were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds <b>1</b> and <b>2</b> exhibited obvious antibacterial activity with a bacteriostatic diam in the range of 16.4–23.5 mm against five pathogenic strains (<i>Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae, Bacillus subtilis</i>, and <i>Proteus</i> spp.). Compounds <b>3–5</b> also exhibited potential antibacterial activity with a bacteriostatic diam in the range of 12.8–19.2 mm. In addition, compounds <b>1</b> and <b>2</b> also have potential value for use as antiseptic agents for cigarette tipping paper.</p>

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Two New Antibacterial Pyrroloquinolines from the Tobacco Endophytic Aspergillus sp.

  • 期刊论文

  • 发表日期：

    2026年1月1日

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  • Song-Yi Ji,
  • Ling Zhang,
  • Yong Xu,
  • Jin Wang,
  • Ying-Liang Zhao,
  • Jian-Duo Zhang,
  • Guang-Yu Yang,
  • Qiu-Fen Hu,
  • Jing Li,
  • Rong Zhang

摘要

To explore more antibacterial natural products, an extract from fermentation products of tobacco endophytic Aspergillus sp. (YATS-225) was investigated. As a result, five pyrroloquinolines (1–5) were isolated. Among them, two newly discovered pyrrolo[1,2-a]quinolin (1 and 2) were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 exhibited obvious antibacterial activity with a bacteriostatic diam in the range of 16.4–23.5 mm against five pathogenic strains (Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae, Bacillus subtilis, and Proteus spp.). Compounds 3–5 also exhibited potential antibacterial activity with a bacteriostatic diam in the range of 12.8–19.2 mm. In addition, compounds 1 and 2 also have potential value for use as antiseptic agents for cigarette tipping paper.