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<p>A novel alkaloid, 2,3-dioxo-1,4-diazabicyclo[3.2.0]heptane-4-carboxylic acid, named oleraciamide I was isolated from <i>Portulaca oleracea</i> L. The structure of the compound was identified by spectroscopic methods, including 1D, 2D NMR, and UHPLC-ESI-Q-TOF/MS. It was found that oleraciamide I could significantly inhibit the production of inflammatory factor IL-1<i>β</i> at 20 μM.</p>

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A Novel Alkaloid from Portulaca oleracea and Its Anti-Inflammatory Bioactivities

  • 期刊论文

  • 发表日期：

    2026年1月1日

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  • Zhiwei Zhang,
  • Jing Liu,
  • Hongzhe Zhang,
  • Yang Du,
  • Xixiang Ying

摘要

A novel alkaloid, 2,3-dioxo-1,4-diazabicyclo[3.2.0]heptane-4-carboxylic acid, named oleraciamide I was isolated from Portulaca oleracea L. The structure of the compound was identified by spectroscopic methods, including 1D, 2D NMR, and UHPLC-ESI-Q-TOF/MS. It was found that oleraciamide I could significantly inhibit the production of inflammatory factor IL-1β at 20 μM.