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<p>A phytochemical investigation of the 80% acetone extract of the fruiting bodies of <i>Ganoderma leucocontextum</i> afforded three new lanostane triterpenoids, 3<i>β</i>-acetyloxy-24,26-dihydroxy-25-methoxy-lanosta-8-en-7,11-dioxo (<b>1</b>), 3<i>β</i>-acetyloxy-11<i>β</i>,26,27-trihydroxylanosta-8,24-dien-7-oxo (<b>2</b>), and 15<i>α</i>-hydroxy-22,23,24,25,26,27-hexanorlanosta-7,9(11)-dien-3,20-dioxo (<b>3</b>), as well as one known compound lanosta-8-en-7,11-dioxo-3<i>β</i>-acetyloxy-24,25,26-trihydroxy (<b>4</b>). The structures of the new compounds were elucidated by spectral methods such as 1D and 2D NMR spectrometry, HR-ESI-MS. The isolated triterpenoids were tested in vitro for cytotoxic activities against five gastric carcinoma cell lines. As a result, <b>1</b> exhibited some cytotoxic activities against all the tested tumor cell lines with IC<sub>50</sub> values less than 20 μM.</p>

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Cytotoxic Lanostane Triterpenoids from Ganoderma leucocontextum

  • 期刊论文

  • 发表日期：

    2026年1月1日

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  • Jiang Hu,
  • Tao Lv,
  • Qiang Li,
  • Feng Gao

摘要

A phytochemical investigation of the 80% acetone extract of the fruiting bodies of Ganoderma leucocontextum afforded three new lanostane triterpenoids, 3β-acetyloxy-24,26-dihydroxy-25-methoxy-lanosta-8-en-7,11-dioxo (1), 3β-acetyloxy-11β,26,27-trihydroxylanosta-8,24-dien-7-oxo (2), and 15α-hydroxy-22,23,24,25,26,27-hexanorlanosta-7,9(11)-dien-3,20-dioxo (3), as well as one known compound lanosta-8-en-7,11-dioxo-3β-acetyloxy-24,25,26-trihydroxy (4). The structures of the new compounds were elucidated by spectral methods such as 1D and 2D NMR spectrometry, HR-ESI-MS. The isolated triterpenoids were tested in vitro for cytotoxic activities against five gastric carcinoma cell lines. As a result, 1 exhibited some cytotoxic activities against all the tested tumor cell lines with IC50 values less than 20 μM.