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<p>A novel piperidine alkaloid, named (7′E)-3-acetyl-1-olefinic-3′,5′-dihydroxymethylphenyl-4′-O-prenylpiperidine alkaloid (<b>1</b>), and six known piperidine alkaloids (<b>2–7</b>) were isolated from highland barley <i>Monascus purpureus</i> for the first time. These compounds <b>1–7</b> were determined by extensive and comprehensive spectral analyses and comparing with their references. Compounds (<b>1–7</b>) were assayed for their inhibitory effects against the increases in ALT and AST levels on H<sub>2</sub>O<sub>2</sub>-induced HepG2 cells. As a result, compounds <b>1</b>, <b>2</b>, and <b>4</b> displayed significant hepatoprotective activities.</p>

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Tetrahydropyridine Alkaloids with Hepatoprotective Activities from Highland Barley Monascus purpureus

  • 期刊论文

  • 发表日期：

    2025年11月18日

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  • Qin-Ge Ma,
  • Wen-Min Liu,
  • Rong-Rui Wei

摘要

A novel piperidine alkaloid, named (7′E)-3-acetyl-1-olefinic-3′,5′-dihydroxymethylphenyl-4′-O-prenylpiperidine alkaloid (1), and six known piperidine alkaloids (2–7) were isolated from highland barley Monascus purpureus for the first time. These compounds 1–7 were determined by extensive and comprehensive spectral analyses and comparing with their references. Compounds (1–7) were assayed for their inhibitory effects against the increases in ALT and AST levels on H2O2-induced HepG2 cells. As a result, compounds 1, 2, and 4 displayed significant hepatoprotective activities.