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<p>New amido-derivatives of 5-fluorouracil were synthesized. Their cytotoxic activity was studied. Antiproliferative activity was found for all 5-fluorouracil derivatives. 2,2′-[5-Fluoro-2,4-dioxopyrimidine-1,3(2<i>H</i>,4<i>H</i>)-diyl]bis[<i>N</i>-(2,6-dimethylphenyl)acetamide] (<b>3e</b>) exhibited the greatest dose-dependent cytotoxicity on HeLa cells; 2,2′ -[5-fluoro-2,4-dioxopyrimidine-1,3(2<i>H</i>,4<i>H</i>)-diyl]bis[<i>N</i>-(2,4-dimethylphenyl)acetamide] (<b>3c</b>), on KML and AKAT cells.</p>

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Synthesis of New Amido-Derivatives of 5-Fluorouracil and their Cytotoxic Activity against Various Continuous Cell Lines

  • 期刊论文

  • 发表日期：

    2025年11月24日

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  • A. D. Matchanov,
  • M. S. Yusufov,
  • T. S. Kholikov,
  • Z. S. Khashimova,
  • R. S. Esanov,
  • Sh. E. Ochilov

摘要

New amido-derivatives of 5-fluorouracil were synthesized. Their cytotoxic activity was studied. Antiproliferative activity was found for all 5-fluorouracil derivatives. 2,2′-[5-Fluoro-2,4-dioxopyrimidine-1,3(2H,4H)-diyl]bis[N-(2,6-dimethylphenyl)acetamide] (3e) exhibited the greatest dose-dependent cytotoxicity on HeLa cells; 2,2′ -[5-fluoro-2,4-dioxopyrimidine-1,3(2H,4H)-diyl]bis[N-(2,4-dimethylphenyl)acetamide] (3c), on KML and AKAT cells.