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<p>The glucoarabinogalactan GAG-Sco with MM 15 kDa was obtained by fractionation of water-soluble polysaccharides from <i>Scutellaria comosa</i> Juz<i>.</i> An analysis of the monosaccharide residues showed that GAG-Sco consisted of arabinose (35.7%), glucose (25.8%), and galactose (27.7%). Chemical analyses and <sup>1</sup>H and <sup>13</sup>C NMR spectroscopic data found that the main chain of the GAG-Sco macromolecule consisted of 1,6-bound D-galactopyranosyl residues. A side chain in the C-2 position contained glucose, arabinose, and the oligosaccharide fragment <i>α-</i>Ara<i>f</i>-(5→1)-<i>α</i>-Ara<i>f</i>. The water-soluble polysaccharide from S. comosa was shown to affect phagocytosis, specifically the phagocytic index of neutrophils.</p>

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Polysaccharides from Scutellaria. II. Structure and Properties of Polysaccharides from Scutellaria comosa

  • 期刊论文

  • 发表日期：

    2025年9月17日

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  • R. K. Rakhmanberdyeva,
  • A. A. Siddikova,
  • Kh.M. Bobakulov,
  • T. A. Petrova,
  • M. Kh. Malikova,
  • A. A. Ismailova

摘要

The glucoarabinogalactan GAG-Sco with MM 15 kDa was obtained by fractionation of water-soluble polysaccharides from Scutellaria comosa Juz. An analysis of the monosaccharide residues showed that GAG-Sco consisted of arabinose (35.7%), glucose (25.8%), and galactose (27.7%). Chemical analyses and 1H and 13C NMR spectroscopic data found that the main chain of the GAG-Sco macromolecule consisted of 1,6-bound D-galactopyranosyl residues. A side chain in the C-2 position contained glucose, arabinose, and the oligosaccharide fragment α-Araf-(5→1)-α-Araf. The water-soluble polysaccharide from S. comosa was shown to affect phagocytosis, specifically the phagocytic index of neutrophils.