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<p>A new megastigmane glycoside (<b>1</b>), viburcoside A, and four known analogs (<b>2–5</b>) were isolated from the methanol extract of Viburnum urceolatum fruits. The structure, including the absolute configuration of compound <b>1</b>, was elucidated by extensive spectroscopic analysis (NMR and HR-ESI-MS), DP4+ NMR and ECD calculations, and enzyme hydrolysis. In the in vitro assay, viburcoside A (<b>1</b>) exhibited the potential inhibition of α-glucosidase with the IC<sub>50</sub> value of 16.03 μM, compared with the positive control acarbose (IC<sub>50</sub> = 18.84 μM).</p>

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Megastigmane Glycosides with α-Glucosidase Inhibitory Activity from Viburnum urceolatum Fruits

  • 期刊论文

  • 发表日期：

    2025年7月19日

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  • Zi-Han Wang,
  • Hong-Juan Zhou,
  • Meng-Ya Yang,
  • Jian-Hua Shao,
  • Chun-Chao Zhao

摘要

A new megastigmane glycoside (1), viburcoside A, and four known analogs (2–5) were isolated from the methanol extract of Viburnum urceolatum fruits. The structure, including the absolute configuration of compound 1, was elucidated by extensive spectroscopic analysis (NMR and HR-ESI-MS), DP4+ NMR and ECD calculations, and enzyme hydrolysis. In the in vitro assay, viburcoside A (1) exhibited the potential inhibition of α-glucosidase with the IC50 value of 16.03 μM, compared with the positive control acarbose (IC50 = 18.84 μM).