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<p>A novel flavonolignan, named 3,3′,4′,5-tetrahydroxy-3′′′,5′′′-dimethoxy-9′,9′′′dihydroxymethyl-4- hydroxyphenyl-4′′′-hydroxy-3′′′,5′′′-dimethoxyphenylflavonolignan (<b>1</b>), together with five known flavonolignan derivatives (<b>2–6</b>) were isolated from <i>Hippophae rhamnoides</i> L. for the first time. Their structures were determined by extensive and comprehensive IR, UV, NMR, MS spectra, as well as reported references. Compounds <b>1–6</b> were evaluated for their hepatoprotective activities on APAP-treated HepG2 cells. As a result, compounds <b>1</b> and <b>2</b> exhibited moderate hepatoprotective activities.</p>

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Structurally Diverse Flavonolignans with Hepatoprotective Activities from the Fruits of Hippophae rhamnoides

  • 期刊论文

  • 发表日期：

    2025年7月24日

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  • Qinge Ma,
  • Wenmin Liu,
  • Rongrui Wei

摘要

A novel flavonolignan, named 3,3′,4′,5-tetrahydroxy-3′′′,5′′′-dimethoxy-9′,9′′′dihydroxymethyl-4- hydroxyphenyl-4′′′-hydroxy-3′′′,5′′′-dimethoxyphenylflavonolignan (1), together with five known flavonolignan derivatives (2–6) were isolated from Hippophae rhamnoides L. for the first time. Their structures were determined by extensive and comprehensive IR, UV, NMR, MS spectra, as well as reported references. Compounds 1–6 were evaluated for their hepatoprotective activities on APAP-treated HepG2 cells. As a result, compounds 1 and 2 exhibited moderate hepatoprotective activities.