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<p>Two novel water-soluble polysaccharides (ALPS-21 and ALPS-32) were isolated and purified from <i>Acanthopanax leucorrhizus</i>. Their structures were investigated by HPGPC, HPLC, IR, methylation and NMR, and the antioxidant activity was evaluated <i>in vitro</i> by 1,1-diphenyl-2-picrylhydrazyl radical (DPPH<sup><b>·</b></sup>), hydroxyl radical (HO<sup><b>·</b></sup>), and 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS<sup><b>·</b>+</sup>) assay. Results showed that ALPS-21 was a 4.36 kDa neutral heteropolysaccharide composed of glucose, galactose, mannose, xylose in a ratio of 3.5:1.3:0.9:2.1, whereas ALPS-32 was a 5.78 kDa acidic heteropolysaccharide composed of glucose, galactose, mannose, and glucopyranuronic acid in a ratio of 4.5:1.3:1.1:1.0. Moreover, ALPS-21 and ALPS-32 can scavenge DPPH<sup><b>·</b></sup>, HO<sup><b>·</b></sup>, and ABTS<sup><b>·</b>+</sup> in a dose-dependent manner, suggesting that ALPS-21 and ALPS-32 may be promising as a potential natural antioxidant.</p>

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Structural Characteristics and Antioxidant Activity of Two Novel Water-Soluble Polysaccharides from Acanthopanax leucorrhizus

  • 期刊论文

  • 发表日期：

    2025年7月19日

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  • H. B. Hu,
  • Z. Y. Cheng,
  • M. H. Han,
  • H. P. Liang,
  • Y. Wu,
  • H. S. Hu,
  • L. L. Zhang

摘要

Two novel water-soluble polysaccharides (ALPS-21 and ALPS-32) were isolated and purified from Acanthopanax leucorrhizus. Their structures were investigated by HPGPC, HPLC, IR, methylation and NMR, and the antioxidant activity was evaluated in vitro by 1,1-diphenyl-2-picrylhydrazyl radical (DPPH·), hydroxyl radical (HO·), and 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS·+) assay. Results showed that ALPS-21 was a 4.36 kDa neutral heteropolysaccharide composed of glucose, galactose, mannose, xylose in a ratio of 3.5:1.3:0.9:2.1, whereas ALPS-32 was a 5.78 kDa acidic heteropolysaccharide composed of glucose, galactose, mannose, and glucopyranuronic acid in a ratio of 4.5:1.3:1.1:1.0. Moreover, ALPS-21 and ALPS-32 can scavenge DPPH·, HO·, and ABTS·+ in a dose-dependent manner, suggesting that ALPS-21 and ALPS-32 may be promising as a potential natural antioxidant.