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<p>Three monosulfated (3-OSO<sub>3</sub>-Hept, 6-OSO<sub>3</sub>-Hept, and 26-OSO<sub>3</sub>-Hept) and two disulfated derivatives (3,26-di-OSO<sub>3</sub>-Hept and 6,26-di-OSO<sub>3</sub>-Hept) were synthesized from 5<i>α</i>-cholestane-3<i>β</i>,6<i>α</i>,7<i>α</i>,8,15<i>α</i>,16<i>β</i>,26-heptaol (Hept) isolated from the starfish <i>Patiria pectinifera</i>. 3-OSO<sub>3</sub>-Hept and 6-OSO<sub>3</sub>-Hept at a nontoxic concentration of 20 μM exhibited synergism with X-rays against SK-MEL-5 melanoma, HT-29 colon carcinoma, and MDA-MB-231 human breast cancer cells. Also, 3-OSO<sub>3</sub>-Hept at this same concentration was 49% effective for preventing migration of SK-MEL-5 cells.</p>

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Anticancer and Radiosensitizing Potential of Sulfated Derivatives of Steroidal 5α-Cholestane-3β,6α,7α,8,15α,16β,26-Heptaol from the Starfish Patiria pectinifera

  • 期刊论文

  • 发表日期：

    2025年5月19日

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  • T. V. Malyarenko,
  • O. S. Malyarenko,
  • S. A. Avilov,
  • A. A. Kicha,
  • A. I. Kalinovsky,
  • R. S. Popov,
  • N. V. Ivanchina

摘要

Three monosulfated (3-OSO3-Hept, 6-OSO3-Hept, and 26-OSO3-Hept) and two disulfated derivatives (3,26-di-OSO3-Hept and 6,26-di-OSO3-Hept) were synthesized from 5α-cholestane-3β,6α,7α,8,15α,16β,26-heptaol (Hept) isolated from the starfish Patiria pectinifera. 3-OSO3-Hept and 6-OSO3-Hept at a nontoxic concentration of 20 μM exhibited synergism with X-rays against SK-MEL-5 melanoma, HT-29 colon carcinoma, and MDA-MB-231 human breast cancer cells. Also, 3-OSO3-Hept at this same concentration was 49% effective for preventing migration of SK-MEL-5 cells.