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<p>Phytochemical investigations of <i>Viburnum chinshanense</i> leaves led to the isolation of one previously undescribed neolignan glycoside, (7<i>S</i>,8<i>S</i>)-7,9,3′,9′-tetrahydroxy-3-methoxy-8-4′-oxyneolignan-4-<i>O</i>-<i>β</i>-D- xylopyranoside (<b>1</b>), and three known analogues (<b>2–4</b>). The chemical structure of the new compound was determined by extensive spectroscopic analysis including 1D and 2D NMR, HR-ESI-MS, and CD spectrum. The sugar group in compound <b>1</b> was identified through acid hydrolysis and HPLC analysis of the chiral monosaccharide derivatives. These known compounds were discovered from the genus <i>Viburnum</i> for the first time. Additionally, the activity evaluation indicated that compounds <b>1–4</b> showed moderate inhibitory effects on <i>α</i>-amylase and <i>α</i>-glucosidase.</p>

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Neolignan Glycosides with α-Amylase and α-Glucosidase Inhibitory Activities from Viburnum chinshanense Leaves

  • 期刊论文

  • 发表日期：

    2025年5月15日

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  • Yu-Tong Yin,
  • Hong-Juan Zhou,
  • Jia Chen,
  • Jian-Hua Shao,
  • Chun-Chao Zhao

摘要

Phytochemical investigations of Viburnum chinshanense leaves led to the isolation of one previously undescribed neolignan glycoside, (7S,8S)-7,9,3′,9′-tetrahydroxy-3-methoxy-8-4′-oxyneolignan-4-O-β-D- xylopyranoside (1), and three known analogues (2–4). The chemical structure of the new compound was determined by extensive spectroscopic analysis including 1D and 2D NMR, HR-ESI-MS, and CD spectrum. The sugar group in compound 1 was identified through acid hydrolysis and HPLC analysis of the chiral monosaccharide derivatives. These known compounds were discovered from the genus Viburnum for the first time. Additionally, the activity evaluation indicated that compounds 1–4 showed moderate inhibitory effects on α-amylase and α-glucosidase.