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<p>Two pyridine alkaloids, 5-ethoxypyridin-2-ol, named olerapyridineol (<b>1</b>) and methyl 5-hydroxynicotinate (<b>2</b>), were obtained from the <i>Portulaca oleracea</i> L., from which compound <b>1</b> was the new compound and compound <b>2</b> was isolated from <i>P. oleracea</i> for the first time. The structure of compound <b>1</b> was identified by UHPLC-ESI-Q-TOF/MS, 1D, 2D NMR. Compounds <b>1–2</b> presented antioxidant activities with IC<sub>50</sub> values of 42.625 ± 0.37, 37.423 ± 0.43 μM. In addition, the anti-inflammatory effects on lipopolysaccharide-stimulated macrophages of compounds <b>1–2</b> were also investigated.</p>

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Two Pyridine Alkaloids from Portulaca oleracea and their Anti-Inflammatory and Antioxidant Activities

  • 期刊论文

  • 发表日期：

    2025年3月25日

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  • Xiaoqian Zhang,
  • Shuangshuo Liu,
  • Wenjuan Wei,
  • Jing Liu,
  • Pengyan Liu,
  • Ying Yang,
  • Xixiang Ying

摘要

Two pyridine alkaloids, 5-ethoxypyridin-2-ol, named olerapyridineol (1) and methyl 5-hydroxynicotinate (2), were obtained from the Portulaca oleracea L., from which compound 1 was the new compound and compound 2 was isolated from P. oleracea for the first time. The structure of compound 1 was identified by UHPLC-ESI-Q-TOF/MS, 1D, 2D NMR. Compounds 1–2 presented antioxidant activities with IC50 values of 42.625 ± 0.37, 37.423 ± 0.43 μM. In addition, the anti-inflammatory effects on lipopolysaccharide-stimulated macrophages of compounds 1–2 were also investigated.