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<p>A new polyketide, namely fusaripotide (<b>1</b>), and five known compounds (<b>2</b>–<b>6</b>) were isolated from the desert-derived fungus <i>Fusarium</i> sp. HM84-3. Their structures were determined by detailed analysis of 1D and 2D NMR and MS data. All the isolates were evaluated for their cytotoxicity and anti-inflammatory activities. Compound <b>2</b> displayed obvious inhibitory activity against human gastric cancer cells (MGC-803) with an IC<sub>50</sub> value of 10.38 μg/mL. Compounds <b>4</b>–<b>6</b> showed different degrees of anti-inflammatory activity at the concentration of 10 μg/mL with an inhibition rate range of 51.2–57.0%.</p>

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Fusaripotide, A New Polyketide from the Desert-Derived Fungus Fusarium sp. HM84-3

  • 期刊论文

  • 发表日期：

    2025年3月27日

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  • Feng-Xiao Wang,
  • Ya-Hui Zhang,
  • Jun Zhang,
  • Zhuang Li,
  • Du-Qiang Luo

摘要

A new polyketide, namely fusaripotide (1), and five known compounds (2–6) were isolated from the desert-derived fungus Fusarium sp. HM84-3. Their structures were determined by detailed analysis of 1D and 2D NMR and MS data. All the isolates were evaluated for their cytotoxicity and anti-inflammatory activities. Compound 2 displayed obvious inhibitory activity against human gastric cancer cells (MGC-803) with an IC50 value of 10.38 μg/mL. Compounds 4–6 showed different degrees of anti-inflammatory activity at the concentration of 10 μg/mL with an inhibition rate range of 51.2–57.0%.