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<p>Three series of <i>N</i>-containing 5<i>α</i>-steroids were synthesized during a search for biologically active steroids from pregn-16-en-3<i>β</i>-ol-20-one. The structures of the synthesized compounds were proved using <sup>1</sup>H NMR, <sup>13</sup>C NMR, and mass spectra. Studies of the <i>in vitro</i> cytotoxic, anti-inflammatory, and antioxidant activity of 14 synthesized steroids identified four compounds with pronounced anti-inflammatory activity and one with cytotoxic activity against colorectal adenocarcinoma cells.</p>

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Transformation of 5α-Pregnenolone Into Some Hydrazones: Synthesis and Biological Activity

  • 期刊论文

  • 发表日期：

    2025年3月26日

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  • N. Sh. Nadaraia,
  • N. N. Barbakadze,
  • T. B. Kvaratskhelia,
  • M. L. Kakhabrishvili,
  • J. Legault,
  • K. G. Mulkidzhanyan,
  • V. D. Mshvildadze

摘要

Three series of N-containing 5α-steroids were synthesized during a search for biologically active steroids from pregn-16-en-3β-ol-20-one. The structures of the synthesized compounds were proved using 1H NMR, 13C NMR, and mass spectra. Studies of the in vitro cytotoxic, anti-inflammatory, and antioxidant activity of 14 synthesized steroids identified four compounds with pronounced anti-inflammatory activity and one with cytotoxic activity against colorectal adenocarcinoma cells.