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<p>A chemical investigation on the whole plant of <i>Hypericum uralum</i> afforded two previously undescribed polycyclic polyprenylated derivatives, hyperuralines A and B (<b>1</b> and <b>2</b>). The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (<sup>1</sup>H–<sup>1</sup>H COSY, HMQC, and HMBC) NMR spectroscopy, together with high-resolution mass spectrometry. The isolated compounds were tested <i>in vitro</i> for cytotoxic activity against three human tumour cell lines. As a result, compound <b>2</b> exhibited modest cytotoxic potential against the three tested tumour cell lines (MGC-803, BGC-823, and SGC-7901) with IC<sub>50</sub> values of 14.6 ± 3.3, 17.5 ± 4.1, 15.7 ± 3.9 μM, respectively.</p>

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Cytotoxic Polyprenylated Acylphloroglucinols from Hypericum uralum

  • 期刊论文

  • 发表日期：

    2025年3月24日

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  • Jiang Hu,
  • Fengming Xu,
  • Guihua Yu,
  • Tao Lv,
  • Qiang Li,
  • Nianhua Jin,
  • Hongzhou Jin

摘要

A chemical investigation on the whole plant of Hypericum uralum afforded two previously undescribed polycyclic polyprenylated derivatives, hyperuralines A and B (1 and 2). The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (1H–1H COSY, HMQC, and HMBC) NMR spectroscopy, together with high-resolution mass spectrometry. The isolated compounds were tested in vitro for cytotoxic activity against three human tumour cell lines. As a result, compound 2 exhibited modest cytotoxic potential against the three tested tumour cell lines (MGC-803, BGC-823, and SGC-7901) with IC50 values of 14.6 ± 3.3, 17.5 ± 4.1, 15.7 ± 3.9 μM, respectively.