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<p>Pyridin-3-ylmethylylidene derivatives of methyl betulonate were synthesized. Six new Pd(II) complexes of them were obtained. The effects of these compounds on A549 (non-small-cell lung carcinoma) and HCT116 cell lines (colon cancer) were assessed by the MTT assay. 3-{(<i>E</i>)-[28-Methoxy-3,28-dioxolup-20(29)-en-2-ylidene]methyl}-1-methylpyridinium tetrafluoroborate exhibited potent cytotoxic activity on HCT116 cell line (IC<sub>50</sub> = 7.21 μM).</p>

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Synthesis, Complexation with Pd(II), and Cytotoxicity of Pyridin-3-Ylmethylylidene Derivatives of Methyl Betulonate

  • 期刊论文

  • 发表日期：

    2025年1月1日

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  • M. S. Denisov,
  • A. O. Voronina,
  • O. A. Maiorova

摘要

Pyridin-3-ylmethylylidene derivatives of methyl betulonate were synthesized. Six new Pd(II) complexes of them were obtained. The effects of these compounds on A549 (non-small-cell lung carcinoma) and HCT116 cell lines (colon cancer) were assessed by the MTT assay. 3-{(E)-[28-Methoxy-3,28-dioxolup-20(29)-en-2-ylidene]methyl}-1-methylpyridinium tetrafluoroborate exhibited potent cytotoxic activity on HCT116 cell line (IC50 = 7.21 μM).