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<p>A novel flavonolignan, named 3-hydroxy-7-O-<i>β</i>-D-glucopyranosyl-7′′-(4′′-methoxyphenyl)-8′′-(9′′-ethyl acetate)-flavonolignan (<b>1</b>), along with eight known flavonolignan derivatives (<b>2</b>–<b>9</b>) were isolated from <i>Citrus medica</i> var. sarcodactylis (Siebold ex Hoola van Nooten) Swingle for the first time. These compounds (<b>1</b>–<b>9</b>) were determined by extensive and comprehensive IR, UV, NMR, MS spectral analyses and compared with the reported references. Compounds <b>1</b>–<b>9</b> were evaluated for their inhibitory effects against the increases in AST and ALT levels on H<sub>2</sub>O<sub>2</sub>-induced HepG2 cells. As a result, compounds <b>1</b> and <b>2</b> displayed moderate hepatoprotective activities.</p>

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Hepatoprotective Flavonolignan from Citrus medica var. sarcodactylis

  • 期刊论文

  • 发表日期：

    2025年1月1日

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  • Qinge Ma,
  • Jiazeng Guo,
  • Wenmin Liu,
  • Rongrui Wei

摘要

A novel flavonolignan, named 3-hydroxy-7-O-β-D-glucopyranosyl-7′′-(4′′-methoxyphenyl)-8′′-(9′′-ethyl acetate)-flavonolignan (1), along with eight known flavonolignan derivatives (2–9) were isolated from Citrus medica var. sarcodactylis (Siebold ex Hoola van Nooten) Swingle for the first time. These compounds (1–9) were determined by extensive and comprehensive IR, UV, NMR, MS spectral analyses and compared with the reported references. Compounds 1–9 were evaluated for their inhibitory effects against the increases in AST and ALT levels on H2O2-induced HepG2 cells. As a result, compounds 1 and 2 displayed moderate hepatoprotective activities.