Scholarlink

<p>A new neolignan derivative, myrisellipin (<b>1</b>), has been isolated from the seeds of <i>Myristica elliptica</i> var. simiarum, together with seven known compounds, licarin A (<b>2</b>), accuminatin (<b>3</b>), butein (<b>4</b>), 3′-hydroxypterostilbene (<b>5</b>), malabaricone B (<b>6</b>), malabaricone C (<b>7</b>), and 3-(3,4,5-trimethoxyphenyl)-2-(E)-propen-1-ol (<b>8</b>). The structure of new compound <b>1</b> was determined through spectroscopic and MS analyses. Among the isolated compounds, <b>1</b>, <b>4</b>, <b>5</b>, <b>7</b>, <b>8</b> showed potent inhibition, with IC<sub>50</sub> values of 16.83 ± 1.18, 17.92 ± 1.28, 25.06 ± 2.01, 22.05 ± 1.74, and 23.58 ± 1.96 μM respectively, against LPS-induced NO generation. In addition, compounds <b>4</b>, <b>5</b>, and <b>8</b> also showed potent DPPH radical scavenging activities, with IC<sub>50</sub> values of 37.02 ± 2.89, 80.36 ± 5.78, and 50.07 ± 4.11 μM, respectively.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Antioxidant and Anti-Inflammatory Constituents from Myristica elliptica var. simiarum

  • 期刊论文

  • 发表日期：

    2025年1月1日

查看全文
  • Chih-Hui Chin,
  • Zih-Rong Chen,
  • Tsung-Hsien Chang,
  • Chia-Ching Liaw,
  • Ping-Jyun Sung,
  • Ming-Jen Cheng,
  • Chien-Ming Huang,
  • Jih-Jung Chen

摘要

A new neolignan derivative, myrisellipin (1), has been isolated from the seeds of Myristica elliptica var. simiarum, together with seven known compounds, licarin A (2), accuminatin (3), butein (4), 3′-hydroxypterostilbene (5), malabaricone B (6), malabaricone C (7), and 3-(3,4,5-trimethoxyphenyl)-2-(E)-propen-1-ol (8). The structure of new compound 1 was determined through spectroscopic and MS analyses. Among the isolated compounds, 1, 4, 5, 7, 8 showed potent inhibition, with IC50 values of 16.83 ± 1.18, 17.92 ± 1.28, 25.06 ± 2.01, 22.05 ± 1.74, and 23.58 ± 1.96 μM respectively, against LPS-induced NO generation. In addition, compounds 4, 5, and 8 also showed potent DPPH radical scavenging activities, with IC50 values of 37.02 ± 2.89, 80.36 ± 5.78, and 50.07 ± 4.11 μM, respectively.