<p>Schizophrenia is one of the most stigmatized mental disorders, hindering access to treatment and social inclusion. Stigma exists in society and among mental health professionals, where negative attitudes can erode patients’ trust and harm therapeutic relationships. Anti-stigma programs seek to reduce prejudice and foster empathy toward those affected. This paper evaluates the effectiveness of anti-stigma programs specifically targeting mental health professionals. The aim is to identify the key elements of successful interventions and derive practical recommendations to improve therapeutic relationships and promote the psychosocial integration of patients with schizophrenia. A systematic literature review was conducted using scientific databases, including PubMed, PsycINFO, Web of Science, and Google Scholar. Both quantitative and qualitative primary studies were included in the analysis, while relevant systematic and scoping reviews were used as contextual background literature. A total of 14 relevant studies were identified and analyzed. The analysis revealed that anti-stigma programs incorporating psychosocial models and direct patient contact were particularly effective in reducing stigmatizing attitudes. Most of the 14 included studies reported significant improvements in mental health professionals’s attitudes toward individuals with schizophrenia. Long-term, interactive, and culturally sensitive interventions were found to yield the most sustainable changes. In contrast, purely educational programs sometimes led to unintended negative effects by reinforcing existing stereotypes. The findings highlight the importance of carefully designing anti-stigma programs to ensure their effectiveness. Psychosocial approaches, which focus on the person behind the diagnosis, are particularly suitable for fostering empathy and trust in therapeutic relationships. Additionally, interventions must be tailored to the specific needs of mental health professionals and adapted to the cultural context to avoid reinforcing biases. The findings demonstrate that anti-stigma programs for mental health professionals can significantly reduce prejudices and improve therapeutic relationships. Interactive, recovery-oriented approaches that involve direct patient contact are particularly effective in achieving sustainable changes in attitudes and behavior. The implementation of such programs can strengthen patients’ trust in psychiatric care and contribute to a more humanistic practice in mental health services.</p>