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<p></p><p>This study reports the synthesis of pyridinium salts achieved by heating 2-chloropyridine with substituted bromoacetophenones in the absence of solvent. The synthesized salt exhibits a high reactivity toward nucleophilic substitution reactions with C-nucleophiles derived from acetonitrile. Furthermore, the resulting salts are efficiently transformed into 2-amino-3-aroylindolizine-1-carboxamides <i>via</i> a cyclization process, leading to a high yield of the desired product. These findings highlight the potential of this synthetic route to produce valuable indolizine derivatives.</p>

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The synthesis of 3-aroyl-1-carboxamide-substituted indolizines

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • Oleksii Y. Kashner,
  • Kyryl O. Bocharov,
  • Gennadii E. Khoroshilov

摘要

This study reports the synthesis of pyridinium salts achieved by heating 2-chloropyridine with substituted bromoacetophenones in the absence of solvent. The synthesized salt exhibits a high reactivity toward nucleophilic substitution reactions with C-nucleophiles derived from acetonitrile. Furthermore, the resulting salts are efficiently transformed into 2-amino-3-aroylindolizine-1-carboxamides via a cyclization process, leading to a high yield of the desired product. These findings highlight the potential of this synthetic route to produce valuable indolizine derivatives.