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<p></p><p>The Biginelli reaction, a three-component synthesis involving an aromatic aldehyde, urea, and ethyl acetoacetate, is a versatile method for producing 3,4-dihydropyrimidin-2(1<i>H</i>)-ones, 3,4-dihydropyrimidine-2(1<i>H</i>)-thiones, and related heterocycles. These compounds have gained significant attention due to their intriguing pharmacological properties and diverse biological activities. In this review, we highlight recent advances in the synthesis and applications of dihydropyrimidones, focusing on their roles in combating cancer, Alzheimer's, microbial infections, tuberculosis, inflammation, malaria, filariasis, hypertension, and other conditions, along with their antioxidant and antiviral activities.</p>

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Perspective on Biginelli reaction: en route toward the development of biologically and industrially relevant dihydropyrimidone-based frameworks

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • Amrit Krishna Mitra,
  • Arghya Ghosh

摘要

The Biginelli reaction, a three-component synthesis involving an aromatic aldehyde, urea, and ethyl acetoacetate, is a versatile method for producing 3,4-dihydropyrimidin-2(1H)-ones, 3,4-dihydropyrimidine-2(1H)-thiones, and related heterocycles. These compounds have gained significant attention due to their intriguing pharmacological properties and diverse biological activities. In this review, we highlight recent advances in the synthesis and applications of dihydropyrimidones, focusing on their roles in combating cancer, Alzheimer's, microbial infections, tuberculosis, inflammation, malaria, filariasis, hypertension, and other conditions, along with their antioxidant and antiviral activities.